{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:07:10Z","timestamp":1789567630903,"version":"build-2803163510"},"reference-count":132,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytoskeleton"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We here describe mouse models with complementary homozygous\n                    <jats:italic>Svil<\/jats:italic>\n                    mutations. In skeletal muscle, Svil\u2010Mut mice express the\n                    <jats:italic>Svil<\/jats:italic>\n                    \u2010encoded N\u2010terminus fused to the \u03b2gal\u2010neo gene\u2010trap tag and lack the highly conserved archvillin C\u2010terminus; Svil\u2010KO mice lack expression of all known\n                    <jats:italic>Svil<\/jats:italic>\n                    \u2010encoded proteins; and Svil\u2010LoxP mice contain loxP sites for tissue\u2010specific disruption of protein expression. Older Svil\u2010KO male mice showed decreased levels of markers for type 1, 2a, and 2b muscle fibers. Male mice showed elevated P\u2010ERK\/ERK signaling during lengthening contractions, consistent with low\u2010level muscle damage such as that in myofibrillar myopathy\u201010 (MFM10) in humans lacking\n                    <jats:italic>SVIL<\/jats:italic>\n                    proteins. Female mice lacking full\u2010length\n                    <jats:italic>Svil<\/jats:italic>\n                    \u2010encoded proteins, including supervillin and archvillin, exhibited reduced body weights and reduced fat mass. Females in both strains exhibited improved glucose tolerance and lower insulin levels following intraperitoneal glucose injections. Hyperinsulinemic\u2010euglycemic clamp experiments showed increased insulin sensitivity in both strains and increased glucose metabolism in adipose tissues in female Svil\u2010Mut mice. The GLUT4 glucose transporter was increased in skeletal muscle in breeder\u2010aged female Svil\u2010KO and Svil\u2010Mut mice. RNA\u2010Seq revealed transcriptional differences in adult male homeostatic muscles that supported roles in muscle differentiation, ERK signaling, and lipid metabolism. A yeast two\u2010hybrid screen identified new\n                    <jats:italic>Svil<\/jats:italic>\n                    candidate interactors, including CH1 domains of muscle\n                    <jats:italic>Z<\/jats:italic>\n                    \u2010line proteins, a potential dimerization site, and Rho GTPase\u2010activating protein (ARHGAP21), a negative regulator of glucose\u2010stimulated insulin secretion in pancreatic beta cells. We suggest that the Svil\u2010Mut, Svil\u2010KO, and Svil\u2010LoxP strains described here will be useful models for understanding signaling within and between tissues regulating glucose metabolism.\n                  <\/jats:p>","DOI":"10.1002\/cm.70196","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:28:00Z","timestamp":1789565280000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Increased Insulin Action, Glucose Metabolism and Muscle Function in Supervillin\u2010Knockout and Supervillin\u2010Mutant Mice"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7840-7044","authenticated-orcid":false,"given":"Tara C.","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Radiology, Division of Cell Biology &amp; Imaging University of Massachusetts Chan Medical School  Worcester Massachusetts 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E.","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology &amp; Kinesiology College of Health &amp; Human Performance, University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5406-6644","authenticated-orcid":false,"given":"Nacima","family":"Hadjout\u2010Rabi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Cell Biology &amp; Imaging University of Massachusetts Chan Medical School  Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7401-4398","authenticated-orcid":false,"given":"Elisabeth R.","family":"Barton","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology &amp; Kinesiology College of Health &amp; Human Performance, University of Florida  Gainesville Florida 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