{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:43:40Z","timestamp":1789821820495,"version":"4.0.1"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,2,4]],"date-time":"2005-02-04T00:00:00Z","timestamp":1107475200000},"content-version":"vor","delay-in-days":8070,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Motility"],"published-print":{"date-parts":[[1983,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Measurements of the mechanical properties of the erythrocyte membrane provide a direct assessment of the proper function of its structural components. To assess the effects of alterations in molecular structure on membrane mechanical properties, measurements have been performed on cells from six individuals whose membranes contain inherited, biochemically characterized structural defects. Because the contribution of the memmbrane skeleton to the mechanical behavior of the membrane is most evident in shear deformation, mechanical experiments were performed to measure the material constants which characterize the response of the membrane to shear force resultants. The surface elastic shear modulus characterizes the elastic response of the membrane; the yield shear resultant is the maximum shear force resultant which the membrane can support elastically; and the plastic viscosity coefficient characterizes the rate of membrane deformation when the elastic limit has been exceeded.<\/jats:p><jats:p>Generally, it was found that when the molecular defect is found to occur in a region of the skeleton which is stress\u2010supporting, the maximum elastic strength of the membrane is reduced. However, the magnitude of the reduction can be quite different for membranes having similar or even identical defects. In some cases the differences can be attributed to the removal of the most fragile cells of the population by the spleen, but other results indicate that the biochemical description of the defects may be incomplete. These results emphasize the need for further refinements both in the biochemical characterization of membrane skeleton structure and in the description and measurement of membrane mechanical properties.<\/jats:p>","DOI":"10.1002\/cm.970030526","type":"journal-article","created":{"date-parts":[[2005,4,11]],"date-time":"2005-04-11T19:33:39Z","timestamp":1113248019000},"page":"609-622","source":"Crossref","is-referenced-by-count":18,"title":["Effects of abnormal cytoskeletal structure on erythrocyte membrane mechanical properties"],"prefix":"10.1002","volume":"3","author":[{"given":"Richard E.","family":"Waugh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110411"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(82)90305-4"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(81)90497-9"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(78)85395-8"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(76)85659-7"},{"key":"e_1_2_1_7_2","first-page":"1","volume-title":"Mechanochemical properties of membrane","author":"Evans E. A.","year":"1978"},{"key":"e_1_2_1_8_2","first-page":"181","article-title":"Mechanics and theromodynamics of biomembranes","volume":"3","author":"Evans E. A.","year":"1979","journal-title":"CRC Crit. Rev. Bioeng."},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"C121","DOI":"10.1152\/ajpcell.1983.244.3.C121","article-title":"The spectrin membrane skeleton of normal and abnormal erythrocytes: A review","volume":"13","author":"Goodman S. R.","year":"1983","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1182\/blood.V60.3.772.772","article-title":"Identification of the molecular defect in the erythrocyte membrane skeleton of some kindreds with hereditary spherocytosis","volume":"60","author":"Goodman S. R.","year":"1982","journal-title":"Blood"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(73)86021-7"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V61.1.1.1","article-title":"The red cell membrane skeleton: Recent progress","volume":"61","author":"Marchesi V. T.","year":"1983","journal-title":"Blood"},{"key":"e_1_2_1_13_2","first-page":"95","volume-title":"Glycoconnectin (PAS2), a membrane attachment site for the human erythrocyte cytoskeleton","author":"Mueller T. J.","year":"1981"},{"key":"e_1_2_1_14_2","first-page":"47a","article-title":"Cytoskeletal alterations in hereditary elliptocytosis","volume":"58","author":"Mueller T. J.","year":"1981","journal-title":"Blood"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(82)84517-7"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(79)85239-X"},{"key":"e_1_2_1_17_2","first-page":"240","article-title":"Abnormalities in the membrane material properties of hereditary spherocytes","volume":"102","author":"Waugh R.","year":"1980","journal-title":"J. Biochem. Eng."},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198211253072203"}],"container-title":["Cell Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcm.970030526","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cm.970030526","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T22:15:01Z","timestamp":1697753701000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cm.970030526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,1]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1983,1]]}},"alternative-id":["10.1002\/cm.970030526"],"URL":"https:\/\/doi.org\/10.1002\/cm.970030526","archive":["Portico"],"relation":{},"ISSN":["0271-6585"],"issn-type":[{"value":"0271-6585","type":"print"}],"subject":[],"published":{"date-parts":[[1983,1]]}}}