{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:43:00Z","timestamp":1790617380471,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,8,3]],"date-time":"2006-08-03T00:00:00Z","timestamp":1154563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2006,8,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>After preliminary studies in 1981, Marshall and Warren conducted a study in which the new bacterium <jats:italic>Helicobacter pylori<\/jats:italic> was cultured. In that series, 100\u2009% of 13 patients with duodenal ulcer were found to be infected. The hypothesis that peptic ulcer was caused by a bacterial infection was not accepted without a fight. Most experts believed that <jats:italic>Helicobacter<\/jats:italic> was a harmless commensal, infecting people who had ulcers for some other reason. In response, Marshall drank a culture of <jats:italic>Helicobacter<\/jats:italic> to prove that the bacteria could infect a healthy person and cause gastritis. The truth behind peptic ulcers was revealed; that is, very young children acquired the <jats:italic>Helicobacter<\/jats:italic> organism, leading to a chronic infection which caused a lifelong susceptibility to peptic ulcers. Marshall developed new treatments for the infection and diagnostic tests which allowed the hypothesis to be evaluated and proven. After 1994 <jats:italic>Helicobacter<\/jats:italic> was generally accepted as the cause of most gastroduodenal diseases including peptic ulcer and gastric cancer. As a result of this knowledge, treatment is a simple procedure, and stomach surgery has become a rarity.<\/jats:p>","DOI":"10.1002\/cmdc.200600153","type":"journal-article","created":{"date-parts":[[2006,8,3]],"date-time":"2006-08-03T14:47:47Z","timestamp":1154616467000},"page":"783-802","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Helicobacter Connections"],"prefix":"10.1002","volume":"1","author":[{"given":"Barry","family":"Marshall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,3]]},"reference":[{"key":"e_1_2_22_1_2","first-page":"705","volume-title":"Alimentary Canal","author":"Ito S.","year":"1967"},{"key":"e_1_2_22_2_2","first-page":"233","volume":"28","author":"Bizzozero G.","year":"1892","journal-title":"Atti R. Accad. Sci. Torino"},{"key":"e_1_2_22_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/2201137a0"},{"key":"e_1_2_22_4_2","first-page":"323","volume-title":"Modern Trends in Gastroenterology","author":"Magnus H. A.","year":"1952"},{"key":"e_1_2_22_5_2","first-page":"1273","volume":"1","author":"Warren J. R.","year":"1983","journal-title":"Lancet"},{"key":"e_1_2_22_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)90114-8"},{"key":"e_1_2_22_7_2","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0140-6736(84)91816-6","volume":"1","author":"Marshall B. J.","year":"1984","journal-title":"Lancet"},{"key":"e_1_2_22_8_2","doi-asserted-by":"crossref","first-page":"439","DOI":"10.5694\/j.1326-5377.1985.tb113444.x","volume":"142","author":"Marshall B. J.","year":"1985","journal-title":"Med. J. Aust."},{"key":"e_1_2_22_9_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1985.tb113443.x"},{"key":"e_1_2_22_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.290.6479.1383"},{"key":"e_1_2_22_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)92145-3"},{"key":"e_1_2_22_12_2","first-page":"11","volume":"29","author":"Marshall B. J.","year":"1988","journal-title":"J. Nucl. Med."},{"key":"e_1_2_22_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91301-P"},{"key":"e_1_2_22_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-4-266"},{"key":"e_1_2_22_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199302043280503"},{"key":"e_1_2_22_16_2","first-page":"15","volume-title":"Helicobacter Pioneers: Firsthand Accounts from the Scientists Who Discovered Helicobacters 1893\u20131983","year":"2002"},{"key":"e_1_2_22_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/41483"}],"container-title":["ChemMedChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcmdc.200600153","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.200600153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:56:13Z","timestamp":1760277373000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cmdc.200600153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,3]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,8,11]]}},"alternative-id":["10.1002\/cmdc.200600153"],"URL":"https:\/\/doi.org\/10.1002\/cmdc.200600153","archive":["Portico"],"relation":{},"ISSN":["1860-7179","1860-7187"],"issn-type":[{"value":"1860-7179","type":"print"},{"value":"1860-7187","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,3]]},"assertion":[{"value":"2006-06-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-08-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}