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These inhibitors were charged phosphate derivatives with restricted capacity to enter cells. Herein, we report the synthesis of five different classes of prodrugs: phosphoramidate; bis\u2010S\u2010acyl thioethyl esters (bis\u2010SATE); bis\u2010pivaloxymethyl (bis\u2010POM); CycloSaligenyl; and phenyl, S\u2010acyl thioethyl mixed phosphate esters (mix\u2010SATE). Prodrugs were studied for stability and activity against the intact parasites. Most prodrugs caused inhibition of the growth of the parasites. The activity of the prodrugs against the parasites appeared to be related to their stability in aqueous buffer.<\/jats:p>","DOI":"10.1002\/cmdc.200700040","type":"journal-article","created":{"date-parts":[[2007,7,6]],"date-time":"2007-07-06T05:19:41Z","timestamp":1183699181000},"page":"1169-1180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Synthesis and Biological Evaluation of Phosphate Prodrugs of 4\u2010Phospho\u2010<scp>D<\/scp> \u2010erythronohydroxamic Acid, an Inhibitor of 6\u2010Phosphogluconate Dehydrogenase"],"prefix":"10.1002","volume":"2","author":[{"given":"Gian 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