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Carbonic anhydrase (CA) VII contributes to this electrophysiological behavior by providing bicarbonate anion, which can mediate current through channels coupled to GABA<jats:sub>A<\/jats:sub> receptors. Among the cytosolic CAs, the mechanism of action and inhibition of CA\u2005VII is less understood. We present herein the pharmacological evaluation of both enantiomers of an indanesulfonamide compound substituted by a pentafluorophenyl moiety against CA\u2005VII and five other human CA isoforms to evaluate their selectivity. The investigated compounds are powerful inhibitors of hCA\u2005VII, with <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values in the range of 1.7\u20133.3\u2005n<jats:sc>M<\/jats:sc>, but their selectivity needs to be improved. 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