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Iminoxilitol derivatives:"},{"key":"e_1_2_3_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200600217"},{"key":"e_1_2_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2004.03.007"},{"key":"e_1_2_3_22_2","doi-asserted-by":"publisher","DOI":"10.1039\/B411473F"},{"key":"e_1_2_3_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/cc060080o"},{"key":"e_1_2_3_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo050521a"},{"key":"e_1_2_3_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/ci00053a005"},{"key":"e_1_2_3_25_3","doi-asserted-by":"publisher","DOI":"10.1021\/ci00063a006"},{"key":"e_1_2_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2004.09.086"},{"key":"e_1_2_3_27_2","unstructured":"The most potent GlcCerase inhibitors known to date are the iminosugar 6\u03b1\u2010nonylisofagomine (IC50=0.6\u2005nM ref.\u2005[13c]) and the iminocyclitol 1\u03b1\u2010nonyliminoxylitol (IC50=6.8\u2005nM Ki=2\u2005nM ref.\u2005[13g]). This last compound has been reported to double the residual activity in fibroblasts from Gaucher patients (ref.\u2005[13g]) at a concentration sensibly lower than that required for NNDNJ for a similar effect (ref.\u2005[14])."},{"key":"e_1_2_3_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.192582899"},{"key":"e_1_2_3_29_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1999.00948.x"}],"container-title":["ChemMedChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcmdc.200700061","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.200700061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T15:26:58Z","timestamp":1760282818000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cmdc.200700061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,27]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,7,9]]}},"alternative-id":["10.1002\/cmdc.200700061"],"URL":"https:\/\/doi.org\/10.1002\/cmdc.200700061","archive":["Portico"],"relation":{},"ISSN":["1860-7179","1860-7187"],"issn-type":[{"value":"1860-7179","type":"print"},{"value":"1860-7187","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,27]]},"assertion":[{"value":"2007-03-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-06-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}