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Among these compounds, high anti\u2010<jats:italic>H.\u2005pylori<\/jats:italic> activities were observed in isoflavones derivatives <jats:bold>4<\/jats:bold>\u2013<jats:bold>7<\/jats:bold>, <jats:bold>19<\/jats:bold>, and <jats:bold>20<\/jats:bold> but exhibited no inhibitory activity against other sorts of bacteria and fungi, for example, <jats:italic>Streptococcus pneumoniae, Bacillus subtilis, Escherichia coli, Pseudomonas fluorescence<\/jats:italic>, and <jats:italic>Aspergillus niger<\/jats:italic>. Genistein derivative <jats:bold>6<\/jats:bold> with the potent activity (MIC=0.39\u2005\u03bcg\u2009mL<jats:sup>\u22121<\/jats:sup>) was &gt;50\u2010fold more than metronidazole, and comparable to the positive control amoxicillin. Additionally, compound <jats:bold>6<\/jats:bold> can significantly attenuate the increase in interleukin\u20108 (IL\u20108) levels in the AGS cells stimulated by <jats:italic>H.\u2005pylori<\/jats:italic> water extract (HPE) at concentrations of 15, 30, and 60<jats:italic>\u2005<\/jats:italic>\u03bcmol\u2009L<jats:sup>\u22121<\/jats:sup>, which did not show any effects on the cell viability.<\/jats:p>","DOI":"10.1002\/cmdc.200700097","type":"journal-article","created":{"date-parts":[[2007,7,12]],"date-time":"2007-07-12T10:01:48Z","timestamp":1184234508000},"page":"1361-1369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Metronidazole\u2013Flavonoid Derivatives as Anti\u2010<i>Helicobacter pylori<\/i> Agents with Potent Inhibitory Activity against HPE\u2010Induced Interleukin\u20108 Production by AGS Cells"],"prefix":"10.1002","volume":"2","author":[{"given":"Huan\u2010Qiu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Sen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu\u2010Ping","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Liang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,8,31]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5418.1328"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm9900671"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.2008.i9"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/34.3.409"},{"key":"e_1_2_8_5_2","unstructured":"\u00a0"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018884322973"},{"key":"e_1_2_8_7_2","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1128\/JCM.38.9.3436-3441.2000","volume":"38","author":"Thoreson A. 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