{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:04:43Z","timestamp":1791464683171,"version":"4.3.4"},"reference-count":170,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,10,8]],"date-time":"2007-10-08T00:00:00Z","timestamp":1191801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2007,11,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>For thousands of years mu opioid agonists such as morphine have been utilized for their analgesic properties. Today, morphine and related compounds are still used as a first line therapy in the treatment of moderate to severe pain. However, despite the clear benefits of mu agonists in pain management, severe side effects such as dependence and respiratory depression are associated with use of these drugs. To date, there are only two approved mu opioid antagonists for use in the treatment of these adverse effects, that is, naloxone and naltrexone. However, many other clinical and therapeutic areas have been linked to mu opioid receptor antagonism. These include treatment of opioid induced pruritis of the skin, obesity, and Parkinson\u2010induced tardive dyskinesia. Currently there are two compounds, <jats:italic>N<\/jats:italic>\u2010methylnaltrexone and alvimopan, under FDA review as possible treatments for opioid induced bowel dysfunction and postoperative ileus. These compounds are of special interest as they are peripherally restricted. This attribute enables treatment of peripheral side effects induced by opioid agonists without reversal of the centrally mediated analgesia of the agonist. In this article we discuss the structural classes of mu opioid antagonists, their potential clinical applications, and review the relevant patents of the last ten years.<\/jats:p>","DOI":"10.1002\/cmdc.200700143","type":"journal-article","created":{"date-parts":[[2007,10,8]],"date-time":"2007-10-08T05:16:54Z","timestamp":1191820614000},"page":"1552-1570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Mu Opioid Receptor Antagonists: Recent Developments"],"prefix":"10.1002","volume":"2","author":[{"given":"Allan\u2005J.","family":"Goodman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Le\u2005Bourdonnec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland\u2005E.","family":"Dolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11,2]]},"reference":[{"key":"e_1_2_6_1_2","volume-title":"Burger\u2019s Medicinal Chemistry and Drug Discovery, Vol.\u20053","author":"Aldrich J. V.","year":"1996"},{"key":"e_1_2_6_2_2","unstructured":"http:\/\/www.medsch.wisc.edu\/painpolicy\/publicat\/monograp\/gdlmono\u2010eng.pdf."},{"key":"e_1_2_6_3_2","unstructured":"http:\/\/www.medsch.wisc.edu\/painpolicy\/publicat\/monograp\/JICWELS01.pdf."},{"key":"e_1_2_6_4_2","volume-title":"Pain. Current Understanding, Emerging Therapies, and Novel Approaches to Drug Discovery","year":"2003"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm9805034"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(97)00474-7"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00072a002"},{"key":"e_1_2_6_7_3","doi-asserted-by":"publisher","DOI":"10.1021\/jm00072a002"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2004.11.007"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2001.7727"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6468(08)70035-3"},{"key":"e_1_2_6_11_2","first-page":"50","volume":"96","author":"Zimmerman D. M.","year":"1990","journal-title":"NIDA Res. Monogr."},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/med.10059"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(81)90355-1"},{"key":"e_1_2_6_14_2","unstructured":"B. Le\u2005Bourdonnec R.\u2005E. Dolle P.\u2005J. Little D.\u2005L. DeHaven\u2010Hudkins D.\u2005D. Wiant N.\u2005C. Conway\u2010James G.\u2005J. Stabley S. Belanger J.\u2005A. Cassel R.\u2005N. DeHaven J.\u2005M. Sutton T. Harrison D. Neighbour Abstracts of Papers 225th ACS National Meeting(New Orleans LA United States) 2003."},{"key":"e_1_2_6_15_2","first-page":"136","volume":"90","author":"Lewis J. W.","year":"1988","journal-title":"NIDA Res. Monogr."},{"key":"e_1_2_6_16_2","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0022-3565(24)39155-4","volume":"294","author":"Broadbear J. H.","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm9810248"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm0604777"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00122a021"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm031126k"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00166a018"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/275332a0"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01548a030"},{"key":"e_1_2_6_24_2","first-page":"112","volume":"34","author":"Zimmerman D. M.","year":"1981","journal-title":"NIDA Res. Monogr."},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00370a019"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm980290i"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(02)00219-5"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(98)00576-9"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00072a001"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm980063g"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm060486f"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm0604878"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(01)00014-2"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(01)00278-5"},{"key":"e_1_2_6_35_2","first-page":"2107","author":"Wentland M. P.","journal-title":"Bioorg. Med. Chem. Lett. 2005, 15"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2003.09.012"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1037\/1064-1297.10.3.213"},{"key":"e_1_2_6_38_2","first-page":"81","volume":"7","author":"Heading C. E.","year":"2006","journal-title":"Curr. Opin. Invest. Drugs"},{"key":"e_1_2_6_39_2","first-page":"694","volume":"87","author":"McCarron M. M.","year":"1991","journal-title":"Pediatrics"},{"key":"e_1_2_6_40_2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1177\/000992287301200112","volume":"12","author":"Synder R.","year":"1973","journal-title":"Clin. Pediatr."},{"key":"e_1_2_6_41_2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1542\/peds.53.4.495","volume":"53","author":"Rumack B. H.","year":"1974","journal-title":"Pediatrics"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1976.tb01493.x"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00422867"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(99)00185-2"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)93162-3"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)91684-7"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.225.1.53"},{"key":"e_1_2_6_48_2","first-page":"2305","volume":"72","author":"Buchner L. H.","year":"1972","journal-title":"N.Y. Med. J."},{"key":"e_1_2_6_49_2","first-page":"157","volume":"8","author":"Loimer N.","year":"1991","journal-title":"J.S.A.T. J."},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.215.13.2108"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt196895568"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1989.10"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)91378-2"},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/48.5.463"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.204.10.932b"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197410000-00010"},{"key":"e_1_2_6_57_2","first-page":"145","volume":"24","author":"Freye E.","year":"1975","journal-title":"Anaesthesist"},{"key":"e_1_2_6_58_2","first-page":"493","volume":"23","author":"Huse K.","year":"1974","journal-title":"Anaesthesist"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-197352030-00033"},{"key":"e_1_2_6_60_2","first-page":"979","volume":"291","author":"Daftery V.","year":"1974","journal-title":"N. Engl. J. Med."},{"key":"e_1_2_6_61_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.224.3.334"},{"key":"e_1_2_6_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)92573-7"},{"key":"e_1_2_6_63_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.1998.tb02707.x"},{"key":"e_1_2_6_64_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.229.9.1167c"},{"key":"e_1_2_6_65_2","first-page":"944","volume":"138","author":"Lewis J. M.","year":"1984","journal-title":"AJR Am. J. Roentgenol."},{"key":"e_1_2_6_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80440-0"},{"key":"e_1_2_6_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(74)80298-2"},{"key":"e_1_2_6_68_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.63.1.112"},{"key":"e_1_2_6_69_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-123-3-199508010-00001"},{"key":"e_1_2_6_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90102-5"},{"key":"e_1_2_6_71_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199406000-00013"},{"key":"e_1_2_6_72_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199001000-00012"},{"key":"e_1_2_6_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)90183-3"},{"key":"e_1_2_6_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(85)80047-0"},{"key":"e_1_2_6_75_2","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.48.2.283"},{"key":"e_1_2_6_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80441-2"},{"key":"e_1_2_6_77_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198508013130514"},{"key":"e_1_2_6_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(88)90083-2"},{"key":"e_1_2_6_79_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00207250"},{"key":"e_1_2_6_80_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200112133452411"},{"key":"e_1_2_6_81_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1992.01820110045007"},{"key":"e_1_2_6_82_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1992.01820110040006"},{"key":"e_1_2_6_83_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200002000-00026"},{"key":"e_1_2_6_84_2","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/35.1.91"},{"key":"e_1_2_6_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(99)00033-2"},{"key":"e_1_2_6_86_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-127-7-199710010-00004"},{"key":"e_1_2_6_87_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410300105"},{"key":"e_1_2_6_88_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199010000-00008"},{"key":"e_1_2_6_89_2","first-page":"81","volume":"25","author":"Wang J. J.","year":"1987","journal-title":"Anaesthesiol. Sin."},{"key":"e_1_2_6_90_2","first-page":"273","volume":"3","author":"Crabtree B. L.","year":"1984","journal-title":"Clin. Pharm."},{"key":"e_1_2_6_91_2","first-page":"119","volume":"6","author":"Fram D. H.","year":"1989","journal-title":"J.S.A.T. J."},{"key":"e_1_2_6_92_2","doi-asserted-by":"publisher","DOI":"10.3109\/00952998009028406"},{"key":"e_1_2_6_93_2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0160-3450(16)31736-6","volume":"22","author":"Willette R. E.","year":"1982","journal-title":"Am. Pharm."},{"key":"e_1_2_6_94_2","unstructured":"Anon National Clearing House for Drug Abuse Information Report Series No.\u200511978 38."},{"key":"e_1_2_6_95_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.131.6.646"},{"key":"e_1_2_6_96_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1973.01750360022003"},{"key":"e_1_2_6_97_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1991.tb01859.x"},{"key":"e_1_2_6_98_2","volume-title":"Treatment approaches: Opioid antagonists. Substance abuse in the United States","author":"O\u2019Brien C. P.","year":"1981"},{"key":"e_1_2_6_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/0010-440X(79)90042-7"},{"key":"e_1_2_6_100_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1978.tb16780.x"},{"key":"e_1_2_6_101_2","doi-asserted-by":"publisher","DOI":"10.3109\/00952997509005662"},{"key":"e_1_2_6_102_2","first-page":"71","volume":"43","author":"O\u2019Brien C. P.","year":"1983","journal-title":"NIDA Res. Monogr."},{"key":"e_1_2_6_103_2","doi-asserted-by":"publisher","DOI":"10.3109\/00952998109009554"},{"key":"e_1_2_6_104_2","first-page":"136","volume":"9","author":"O\u2019Brien C. P.","year":"1976","journal-title":"NIDA Res. Monogr."},{"key":"e_1_2_6_105_2","first-page":"114","volume":"9","author":"Resnick R.","year":"1976","journal-title":"NIDA Res. Monogr."},{"key":"e_1_2_6_106_2","first-page":"88","volume":"9","author":"Thomas M.","year":"1976","journal-title":"NIDA Res. Monogr."},{"key":"e_1_2_6_107_2","first-page":"84","volume":"9","author":"Resnick R. B.","year":"1976","journal-title":"NIDA Res. Monogr."},{"key":"e_1_2_6_108_2","doi-asserted-by":"publisher","DOI":"10.3109\/00952997809028000"},{"key":"e_1_2_6_109_2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0022-3565(25)32374-8","volume":"216","author":"Mello N. K.","year":"1981","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_6_110_2","first-page":"1978","author":"Renault P. F.","journal-title":"Bull. Narc."},{"key":"e_1_2_6_111_2","first-page":"93","volume":"9","author":"Brahen L.","year":"1976","journal-title":"NIDA Res. Monogr."},{"key":"e_1_2_6_112_2","first-page":"158","volume":"9","author":"Goldstein A.","year":"1976","journal-title":"NIDA Res. Monogr."},{"key":"e_1_2_6_113_2","first-page":"106","volume":"9","author":"Landsberg R.","year":"1976","journal-title":"NIDA Res. Monogr."},{"key":"e_1_2_6_114_2","first-page":"505","volume":"41","author":"Stone\u2010Washton N.","year":"1982","journal-title":"NIDA Res. Monogr."},{"key":"e_1_2_6_115_2","first-page":"109","volume":"34","author":"Resnick R.","year":"1981","journal-title":"NIDA Res. Monogr."},{"key":"e_1_2_6_116_2","doi-asserted-by":"publisher","DOI":"10.3109\/10826088009040057"},{"key":"e_1_2_6_117_2","first-page":"77","volume":"9","author":"Parwatikar S.","year":"1976","journal-title":"NIDA Res. Monogr."},{"key":"e_1_2_6_118_2","first-page":"70","volume":"9","author":"Haas N.","year":"1976","journal-title":"NIDA Res. Monogr."},{"key":"e_1_2_6_119_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7352279"},{"key":"e_1_2_6_120_2","first-page":"257","volume":"8","author":"Senft R. A.","year":"1991","journal-title":"J.S.A.T. J."},{"key":"e_1_2_6_121_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(85)90136-2"},{"key":"e_1_2_6_122_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1982.04290110077013"},{"key":"e_1_2_6_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90576-Q"},{"key":"e_1_2_6_124_2","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1681\/ASN.V113514","volume":"11","author":"Pauli\u2010Magnus C.","year":"2000","journal-title":"J. Am. Soc. Nephrol."},{"key":"e_1_2_6_125_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70292-6"},{"key":"e_1_2_6_126_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)04176-1"},{"key":"e_1_2_6_127_2","first-page":"1022","volume":"91","author":"Carson K. L.","year":"1996","journal-title":"Am. J. Gastroenterol."},{"key":"e_1_2_6_128_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70225-3"},{"key":"e_1_2_6_129_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v60n0906"},{"key":"e_1_2_6_130_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-199603000-00011"},{"key":"e_1_2_6_131_2","first-page":"423","volume":"57","author":"Bystritsky","year":"1996","journal-title":"J. Clin. Psychiatry"},{"key":"e_1_2_6_132_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)91525-5"},{"key":"e_1_2_6_133_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.10.1574"},{"key":"e_1_2_6_134_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.23.2847"},{"key":"e_1_2_6_135_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddstr.2005.05.011"},{"key":"e_1_2_6_136_2","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/S0022-3565(24)37432-4","volume":"285","author":"Zhang M.","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_6_137_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(03)00188-6"},{"key":"e_1_2_6_138_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.715455"},{"key":"e_1_2_6_139_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.12.3510"},{"key":"e_1_2_6_140_2","doi-asserted-by":"publisher","DOI":"10.1054\/npep.1999.0050"},{"key":"e_1_2_6_141_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7063865"},{"key":"e_1_2_6_142_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(93)90557-A"},{"key":"e_1_2_6_143_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91698-Z"},{"key":"e_1_2_6_144_2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0022-3565(25)12485-3","volume":"253","author":"Shaw W. N.","year":"1990","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_6_145_2","first-page":"1399","volume":"284","author":"Statnick M. A.","year":"2003","journal-title":"Am. J. Physiol."},{"key":"e_1_2_6_146_2","first-page":"387","volume":"15","author":"Shaw W. N.","year":"1991","journal-title":"Int. J. Obes."},{"key":"e_1_2_6_147_2","unstructured":"C.\u2005H. Mitch M.\u2005L. Heiman F.\u2005C. Tinsley P.\u2005J. Emmerson D.\u2005K. Sindelar M.\u2005A. Statnick Abstracts of Papers 228th ACS National Meeting(Philadelphia PA United States) 2004."},{"key":"e_1_2_6_148_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1E615"},{"key":"e_1_2_6_149_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-005-0035-7"},{"key":"e_1_2_6_150_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.15.5.541"},{"key":"e_1_2_6_151_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(01)00783-8"},{"key":"e_1_2_6_152_2","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2000.105037"},{"key":"e_1_2_6_153_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043453036"},{"key":"e_1_2_6_154_2","first-page":"378","volume":"2","author":"Galligan J. J.","year":"2000","journal-title":"Curr. Opin. Cent. Peripher. Nerv. Syst. Inves. Drugs"},{"key":"e_1_2_6_155_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(01)00784-X"},{"key":"e_1_2_6_156_2","first-page":"1496","volume":"3","author":"Azodo I. A.","year":"2002","journal-title":"Curr. Opin. Invest. Drugs"},{"key":"e_1_2_6_157_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.14.4.479"},{"key":"e_1_2_6_158_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2004.12.001"},{"key":"e_1_2_6_159_2","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2001.112680"},{"key":"e_1_2_6_160_2","unstructured":"C.\u2005H.Mitch D.\u2005M.Zimmerman EP287339 1988."},{"key":"e_1_2_6_161_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00041a003"},{"key":"e_1_2_6_162_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00004a056"},{"key":"e_1_2_6_163_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo951403y"},{"key":"e_1_2_6_164_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00538a065"},{"key":"e_1_2_6_165_2","unstructured":"B.Le\u2005Bourdonnec R.\u2005E.Dolle WO 04\/014310 2004."},{"key":"e_1_2_6_166_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)82490-9"},{"key":"e_1_2_6_167_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00125a043"},{"key":"e_1_2_6_168_2","first-page":"907","volume":"27","author":"Little P. J.","year":"2001","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_6_169_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.05.123"}],"container-title":["ChemMedChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcmdc.200700143","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.200700143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T18:47:19Z","timestamp":1760294839000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cmdc.200700143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,2]]},"references-count":170,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2007,11,12]]}},"alternative-id":["10.1002\/cmdc.200700143"],"URL":"https:\/\/doi.org\/10.1002\/cmdc.200700143","archive":["Portico"],"relation":{},"ISSN":["1860-7179","1860-7187"],"issn-type":[{"value":"1860-7179","type":"print"},{"value":"1860-7187","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,2]]},"assertion":[{"value":"2007-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-11-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}