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This literature analysis revealed that failure to sustain high <jats:sup>.<\/jats:sup>NO concentrations is common to all cancers. In cervical, gastric, colorectal, breast, and lung cancer, the cause of this failure is the inadequate expression of inducible nitric oxide synthase (iNOS), resulting from the inhibition of iNOS expression by TGF\u2010\u03b21 at the mRNA level. In bladder, renal, and prostate cancer, the reason for the insufficient <jats:sup>.<\/jats:sup>NO levels is the depletion of arginine, resulting from arginase overexpression. Arginase competes with iNOS for arginine, catalyzing its hydrolysis to ornithine and urea. In gliomas and ovarian sarcomas, low <jats:sup>.<\/jats:sup>NO levels are caused by inhibition of iNOS by <jats:italic>N<\/jats:italic>\u2010chlorotaurine, produced by infiltrating neutrophils. Stimulated neutrophils express myeloperoxidase, catalyzing H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> oxidation of Cl<jats:sup>\u2212<\/jats:sup> to HOCl, which N\u2010chlorinates taurine at its concentration of 19\u2005m<jats:sc>M<\/jats:sc> in neutrophils. In squamous cell carcinomas of the skin, ovarian cancers, lymphomas, Hodgkin's disease, and breast cancers, low <jats:sup>.<\/jats:sup>NO concentrations arise from the inhibition of iNOS by <jats:italic>N<\/jats:italic>\u2010bromotaurine, produced by eosinophil\u2010peroxidase\u2010expressing infiltrating eosinophils. Eosinophil peroxidase catalyzes the H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> oxidation of Br<jats:sup>\u2212<\/jats:sup> to HOBr, which N\u2010brominates taurine to <jats:italic>N<\/jats:italic>\u2010bromotaurine at its concentration of 15\u2005m<jats:sc>M<\/jats:sc> in eosinophils. In microvascularized tumors, the <jats:sup>.<\/jats:sup>NO concentration is further depleted; <jats:sup>.<\/jats:sup>NO is rapidly consumed by red blood cells (RBCs) through S\u2010nitrosation of RBC glutathione and hemoglobin, and by oxidation to nitrate by RBC oxyhemoglobin. Angiogenesis\u2010inhibiting antibodies are currently used to treat cancers; their mode of action is not, as previously thought, reduction of the tumor O<jats:sub>2<\/jats:sub> or nutrient supply. 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