{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:47:46Z","timestamp":1791395266634,"version":"4.3.3"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,12,9]],"date-time":"2008-12-09T00:00:00Z","timestamp":1228780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2009,1,12]]},"DOI":"10.1002\/cmdc.200800321","type":"journal-article","created":{"date-parts":[[2008,12,9]],"date-time":"2008-12-09T18:11:08Z","timestamp":1228846268000},"page":"49-51","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Assessing the Bioisosterism of the Trifluoromethyl Group with a Protease Probe"],"prefix":"10.1002","volume":"4","author":[{"given":"Monika","family":"Jagodzinska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Huguenot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Candiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Zanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,5]]},"reference":[{"key":"e_1_2_3_1_2","unstructured":"\u00a0"},{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-1202-2_3"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr030685w"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr030143e"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol702434t"},{"key":"e_1_2_3_6_2","unstructured":"\u00a0"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1131943"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200300906"},{"key":"e_1_2_3_9_2","unstructured":"\u00a0"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.200500205"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfluchem.2006.01.011"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1039\/b405955g"},{"key":"e_1_2_3_13_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867053363540"},{"key":"e_1_2_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.200700290"},{"key":"e_1_2_3_15_2","unstructured":"\u00a0"},{"key":"e_1_2_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.05.068"},{"key":"e_1_2_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(02)00262-0"},{"key":"e_1_2_3_18_2","unstructured":"\u00a0"},{"key":"e_1_2_3_19_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007475200"},{"key":"e_1_2_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(01)00104-4"},{"key":"e_1_2_3_21_2","doi-asserted-by":"publisher","DOI":"10.1110\/ps.48401"},{"key":"e_1_2_3_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm049145x"},{"key":"e_1_2_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2007.02.076"},{"key":"e_1_2_3_24_2","unstructured":"\u00a0"},{"key":"e_1_2_3_25_2","unstructured":"A.Oliva G.De\u2005Cillis F.Grams V.Livi G.Zimmermann E.Menta H.\u2010W.Krell PCT Int. Appl. WO 9858925 1998; ["},{"key":"e_1_2_3_25_3","first-page":"95560","volume":"130","year":"1998","journal-title":"Chem. Abstr."},{"key":"e_1_2_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2004.12.016"},{"key":"e_1_2_3_27_2","doi-asserted-by":"publisher","DOI":"10.2174\/1385272033486567"},{"key":"e_1_2_3_28_2","unstructured":"\u00a0"},{"key":"e_1_2_3_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00085a004"},{"key":"e_1_2_3_30_2","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0022-2275(20)42036-X","volume":"32","author":"Stoll G. H.","year":"1991","journal-title":"J. Lipid Res."},{"key":"e_1_2_3_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo01118a002"},{"key":"e_1_2_3_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01166a014"},{"key":"e_1_2_3_33_2","unstructured":"\u00a0"},{"key":"e_1_2_3_34_2","first-page":"125","author":"Roche A. J.","year":"2004","journal-title":"J. Fluorine Chem."},{"key":"e_1_2_3_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/1099-0690(20021)2002:2<309::AID-EJOC309>3.0.CO;2-V"},{"key":"e_1_2_3_36_2","unstructured":"An interpretation of this strong effect of theparasubstituent on the 5\u2010benzyl residue of the barbiturates which should occupy the S2\u2032 subsite of the enzymes is difficult in the absence of structural data on the binding of these ligands to MMPs. Attempts to obtain the crystallographic structure of CF3\u2010barbiturates such as1in complex with a truncated catalytic domain of MMP\u20109 have been so far unsuccessful. Only a few crystallographic structures of MMP\u20109 complexes have been reported owing to the instability of full\u2010length MMP\u20109. See also reference\u2005[6a]."}],"container-title":["ChemMedChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcmdc.200800321","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.200800321","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cmdc.200800321","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.200800321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T14:00:15Z","timestamp":1760277615000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cmdc.200800321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,5]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1,12]]}},"alternative-id":["10.1002\/cmdc.200800321"],"URL":"https:\/\/doi.org\/10.1002\/cmdc.200800321","archive":["Portico"],"relation":{},"ISSN":["1860-7179","1860-7187"],"issn-type":[{"value":"1860-7179","type":"print"},{"value":"1860-7187","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,5]]},"assertion":[{"value":"2008-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-01-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}