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Psoralens, well\u2010known photo\u2010chemotherapeutic agents, were found to be efficient at inducing erythroid differentiation of K562 cells, an in vitro cell line isolated from the pleural effusion of a patient with chronic myelogenous leukemia in blast crisis. The effects of crude pre\u2010irradiated solutions of 5\u2010methoxypsoralen on erythroid differentiation of human leukemic K\u2010562 cells were evaluated. 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