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This work involved a high\u2010throughput screen of a focussed kinase set of \u223c3400 compounds to identify potent and parasite\u2010selective inhibitors of an enzymatic <jats:italic>Leishmania<\/jats:italic> CRK3\u2013cyclin\u20056 complex. The aim of this study is to provide chemical validation that <jats:italic>Leishmania<\/jats:italic> CRK3\u2013CYC6 is a drug target. Eight hit series were identified, of which four were followed up. 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