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The cytotoxic activities of compounds <jats:bold>1<\/jats:bold>\u2013<jats:bold>4<\/jats:bold> were tested against pancreatic carcinoma (PANC\u20101), erythroleukemia (K562), and two glioblastoma multiform (U87 and LN\u2010229) human cell lines; they show very high antiproliferative activity, with IC<jats:sub>50<\/jats:sub> values in the 150\u2013700\u2005n<jats:sc>M<\/jats:sc> range after incubation for 72\u2005h. Distribution of cellular DNA upon treatment with <jats:bold>1<\/jats:bold>\u2013<jats:bold>4<\/jats:bold> revealed that whereas compounds <jats:bold>1<\/jats:bold>\u2013<jats:bold>3<\/jats:bold> induce apoptosis in most of the cell lines, compound <jats:bold>4<\/jats:bold> does not affect cell viability in any cell line tested, indicating a possible difference in cytotoxic mechanism. Studies with the daunomycin\u2010resistant K562\/R cell line expressing P\u2010glycoprotein (Pgp) showed that compounds <jats:bold>1<\/jats:bold>\u2013<jats:bold>4<\/jats:bold> are not substrates of this protein efflux pump, indicating that these compounds do not induce acquisition of multidrug resistance, which is associated with the overexpression of Pgp.<\/jats:p>","DOI":"10.1002\/cmdc.201100432","type":"journal-article","created":{"date-parts":[[2011,12,13]],"date-time":"2011-12-13T08:28:59Z","timestamp":1323764939000},"page":"301-310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Study of the Anticancer Properties of Tin(IV) Carboxylate Complexes on a Panel of Human Tumor Cell Lines"],"prefix":"10.1002","volume":"7","author":[{"given":"Lourdes","family":"Rocamora\u2010Reverte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefan\u00eda","family":"Carrasco\u2010Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Ceballos\u2010Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjiv","family":"Prashar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran N.","family":"Kalu\u0111erovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Ferragut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"G\u00f3mez\u2010Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,13]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/222385a0"},{"key":"e_1_2_6_2_2","volume-title":"Platinum and Other Coordination Compounds in Cancer Chemotherapy","year":"1988"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.200600151"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1039\/B712656P"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0010-8545(95)01216-8"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-8545(98)00268-9"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.12.026"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1039\/b707310k"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1039\/b707440a"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm040763n"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1039\/B707077M"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0898-8838(09)00201-3"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2007.11.013"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1039\/b508531b"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-8545(00)00404-5"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-5780-3_27"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1155\/MBD.1998.179"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1515\/MGMC.1999.22.11.661"},{"key":"e_1_2_6_19_2","doi-asserted-by":"crossref","unstructured":"A. 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