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In addition to its classical actions, 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> exerts pleiotropic effects in a wide variety of target tissues and cell types, often in an autocrine\/paracrine fashion. These biological activities of 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> have suggested a multitude of potential therapeutic applications for the vitamin\u2005D hormone in the treatment of hyperproliferative disorders (e.g. cancer and psoriasis), immune dysfunction (autoimmune diseases), and endocrine disorders (e.g. hyperparathyroidism). However, the calcemic effects induced by 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>\u2014hypercalcemia, increased bone resorption, and soft tissue calcification\u2014limit the use of the natural ligand in these clinical applications. Therefore, numerous 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> analogues have been synthesized with the intent of producing therapeutic agents devoid of hypercalcemic and hyperphosphatemic side effects. To this aim, much attention has been focused on the development of 19\u2010nor\u2010vitamin\u2005D<jats:sub>3<\/jats:sub> derivatives that lack the ring\u2010A exocyclic methylene group (C19). In this review, the 19\u2010nor\u20101,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> analogues are classified according to modifications made at the A\u2010ring, the side chain, or both the A\u2010ring and side chain, as well as other positions. The biological activities of these 19\u2010nor\u20101,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> analogues are summarized and their structure\u2013activity relationships and binding features with the vitamin\u2005D receptor (VDR) are discussed.<\/jats:p>","DOI":"10.1002\/cmdc.201300160","type":"journal-article","created":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T13:28:27Z","timestamp":1371734907000},"page":"1249-1260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Recent Developments of 19\u2010Nor\u20101,25\u2010dihydroxyvitamin\u2005D<sub>3<\/sub> 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