{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T19:15:36Z","timestamp":1771528536034,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,7,23]],"date-time":"2013-07-23T00:00:00Z","timestamp":1374537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A series of novel N\u2010substituted sophocarpinic acid derivatives was designed, synthesized, and evaluated for their anti\u2010enteroviral activities against coxsackievirus type\u2005B3 (CVB3) and coxsackievirus type\u2005B6 (CVB6) in Vero cells. Structure\u2013activity relationship analysis revealed that the introduction of a benzenesulfonyl moiety on the 12\u2010nitrogen atom in (<jats:italic>E<\/jats:italic>)\u2010\u03b2,\u03b3\u2010sophocarpinic acid might significantly enhance anti\u2010CVB3 activity. Among the derivatives, (<jats:italic>E<\/jats:italic>)\u201012\u2010<jats:italic>N<\/jats:italic>\u2010(<jats:italic>m<\/jats:italic>\u2010cyanobenzenesulfonyl)\u2010\u03b2,\u03b3\u2010sophocarpinic acid (<jats:bold>11\u2009m<\/jats:bold>), possessing a <jats:italic>meta<\/jats:italic>\u2010cyanobenzenesulfonyl group, exhibited potent activity against CVB3 with a selectivity index (SI) of 107. Furthermore, compound <jats:bold>11\u2009m<\/jats:bold> also showed a good oral pharmacokinetic profile, with an AUC value of 7.29\u2005\u03bc<jats:sc>M<\/jats:sc>\u2009h<jats:sup>\u22121<\/jats:sup> in rats, and good safety through the oral route in mice, with an LD<jats:sub>50<\/jats:sub> value of &gt;1000\u2005mg\u2009kg<jats:sup>\u22121<\/jats:sup>; these values suggest a druggable characteristic. Therefore, compound <jats:bold>11\u2009m<\/jats:bold> was selected for further investigation as a promising CVB3 inhibitor. We consider (<jats:italic>E<\/jats:italic>)\u2010\u03b2,\u03b3\u2010<jats:italic>N<\/jats:italic>\u2010(benzenesulfonyl)sophocarpinic acids to be a novel class of anti\u2010CVB3 agents.<\/jats:p>","DOI":"10.1002\/cmdc.201300224","type":"journal-article","created":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T09:38:15Z","timestamp":1374658695000},"page":"1545-1553","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Synthesis and Biological Evaluation of N\u2010Substituted Sophocarpinic Acid Derivatives as Coxsackievirus\u2005B3 Inhibitors"],"prefix":"10.1002","volume":"8","author":[{"given":"Li\u2010Mei","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2010Xiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong\u2010Mei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zong\u2010Gen","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010Dong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Huan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan\u2010Qing","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,23]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-81-5-1361"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.326"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(01)00206-6"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.1.261"},{"key":"e_1_2_6_5_2","first-page":"177","volume":"323","author":"Marchant D.","year":"2008","journal-title":"Curr. 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