{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:34:01Z","timestamp":1778636041299,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T00:00:00Z","timestamp":1383177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>PET radiotracer development to target in vivo P\u2010glycoprotein (P\u2010gp) could be an important strategy for the early diagnosis of neurodegenerative disorders such as Alzheimer\u2019s disease (AD). Indeed, as a dysfunction of P\u2010gp is responsible for the accumulation of \u03b2\u2010amyloid plaques (a hallmark of AD) in brain parenchyma, P\u2010gp is the cause of AD onset. P\u2010gp substrates and inhibitors are useful for imaging the activity or expression of this protein, respectively; herein we discuss the in vivo evaluation of some <jats:sup>11<\/jats:sup>C radiotracers with P\u2010gp\u2010inhibitory activity, such as [<jats:sup>11<\/jats:sup>C]MC18 and [<jats:sup>11<\/jats:sup>C]MC113, as well as P\u2010gp substrates [<jats:sup>11<\/jats:sup>C]MC266 and [<jats:sup>11<\/jats:sup>C]MC80. Moreover, the radiosynthesis of all these P\u2010gp probes is reported.<\/jats:p>","DOI":"10.1002\/cmdc.201300362","type":"journal-article","created":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T06:03:51Z","timestamp":1383199431000},"page":"38-42","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["PET Radiotracers for Imaging P\u2010glycoprotein: The Challenge for Early Diagnosis in AD"],"prefix":"10.1002","volume":"9","author":[{"given":"Marcello","family":"Leopoldo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marialessandra","family":"Contino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Berardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Perrone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola Antonio","family":"Colabufo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,31]]},"reference":[{"key":"e_1_2_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc706"},{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.39.1.361"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.16.1295"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.2174\/156802609787521553"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm900743c"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.4236\/aad.2013.21003"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00113.x"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.2174\/156802610792928068"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-8051(03)00078-7"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm800510m"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2009.03.004"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm900940f"},{"key":"e_1_2_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2010.06.057"},{"key":"e_1_2_3_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm900485a"},{"key":"e_1_2_3_15_2","doi-asserted-by":"publisher","DOI":"10.2174\/156802610792928068"},{"key":"e_1_2_3_16_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-120319"},{"key":"e_1_2_3_17_2","doi-asserted-by":"publisher","DOI":"10.2174\/138920011798357015"},{"key":"e_1_2_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201100469"},{"key":"e_1_2_3_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/cn100078a"},{"key":"e_1_2_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-010-0313-1"},{"key":"e_1_2_3_21_2","unstructured":"J. M\u00fcllauer R. Karch J.\u2005P. Bankstahl M. Bankstahl J. Stanek T. Wanek S. Mairinger M. M\u00fcller W. L\u00f6scher O. Langer C. Kuntner Nucl. Med. Biol.\u00ad2013 DOI:."},{"key":"e_1_2_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-004-0961-2"},{"key":"e_1_2_3_23_2","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-05-0402"},{"key":"e_1_2_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2007.09.039"},{"key":"e_1_2_3_25_2","unstructured":"6 7\u2010Dimethoxy\u20102\u2010{3\u2010[4\u2010[11C]methoxy\u20103 4\u2010dihydro\u20102H\u2010naphthalen\u2010 (1E)\u2010ylidene]propyl}\u20101 2 3 4\u2010tetrahydroisoquinoline: K. Leung Molecular Imaging and Contrast Agent Database (MICAD) 2010."},{"key":"e_1_2_3_26_2","unstructured":"6 7\u2010Dimethoxy\u20102\u2010[3\u2010(5\u2010[11C]methoxy\u20101 2 3 4\u2010tetrahydronaphthalen\u20101\u2010yl)propyl]\u20101 2 3 4\u2010tetrahydroisoquinoline: K. Leung Molecular Imaging and Contrast Agent Database (MICAD) 2010."},{"key":"e_1_2_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2010.06.097"},{"key":"e_1_2_3_28_2","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0022-3565(24)29270-3","volume":"299","author":"Polli J. W.","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_3_29_2","first-page":"338","volume":"62","author":"Kangas L.","year":"1984","journal-title":"Med. Biol."},{"key":"e_1_2_3_30_2","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.107.017434"},{"key":"e_1_2_3_31_2","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.105.005421"},{"key":"e_1_2_3_32_2","unstructured":"O\u2010[11C]Methyl derivative of 6 7\u2010dimethoxy\u20102\u2010(4\u2010methoxybiphenyl\u20104\u2010ylmethyl)\u20101 2 3 4\u2010tetrahydroisoquinoline: A. Chopra Molecular Imaging and Contrast Agent Database (MICAD) 2013."},{"key":"e_1_2_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2012.08.005"}],"container-title":["ChemMedChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcmdc.201300362","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.201300362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:32:23Z","timestamp":1760257943000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cmdc.201300362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,31]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1002\/cmdc.201300362"],"URL":"https:\/\/doi.org\/10.1002\/cmdc.201300362","archive":["Portico"],"relation":{},"ISSN":["1860-7179","1860-7187"],"issn-type":[{"value":"1860-7179","type":"print"},{"value":"1860-7187","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,31]]},"assertion":[{"value":"2013-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}