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However, this approach is based on a rigid design that implies the ad\u2005hoc synthesis of each cyclodextrin\u2010targeting agent conjugate. We hypothesized that: 1)\u2005a modular design that decouples the carrier function from the targeting function leads to a flexible system, 2)\u2005combining the reactivity of the vinyl sulfone group toward biomolecules that act as targeting agents with the ability of cyclodextrin to form complexes with a wide range of drugs may yield a versatile system that allows the targeting of different organs with different drugs, and 3)\u2005the higher reactivity of histidine residues toward the vinyl sulfone group can be exploited to couple the cyclodextrin to the targeting system with a degree of regioselectivity. 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