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The antibacterial activity of these systems has been established against a panel of Gram\u2010positive and Gram\u2010negative bacteria, with activity mostly against the former, which in some cases is very potent. Data consistent with modes of action against undecaprenylpyrophosphate synthase (UPPS) and\/or RNA polymerase (RNAP) for a small subset of the library has been obtained. The most active compounds have been shown to exhibit binding at known binding sites of streptolydigin and myxopyronin at UPPS and RNAP. These systems offer potential for their antibacterial activity, and further demonstrate the use of natural products as biologically validated starting points for drug discovery.<\/jats:p>","DOI":"10.1002\/cmdc.201402093","type":"journal-article","created":{"date-parts":[[2014,5,18]],"date-time":"2014-05-18T18:52:16Z","timestamp":1400439136000},"page":"1826-1837","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["A Detailed Study of Antibacterial 3\u2010Acyltetramic Acids and 3\u2010Acylpiperidine\u20102,4\u2010diones"],"prefix":"10.1002","volume":"9","author":[{"given":"Yong\u2010Chul","family":"Jeong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Bikadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eszter","family":"Hazai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark G.","family":"Moloney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,18]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.293.5536.1786"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2011.00284.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2011.08.002"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1176667"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2011.08.003"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2010.508069"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2010.62"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05828.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2201"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200600350"},{"key":"e_1_2_6_10_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200600350"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1657"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1039\/c003211p"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr00038a009"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.47.257"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.69.2.1305-1307.2003"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408639102"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja9056079"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/np0202778"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.07.017"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm701356q"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00457-09"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00702-09"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja2041964"},{"key":"e_1_2_6_24_2","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.1248\/cpb.32.4197","volume":"32","author":"Katsuo K.","year":"1984","journal-title":"Chem. 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