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In our earlier work, such an extract showed better potency than artemisinin alone against both chloroquine\u2010sensitive and \u2010resistant parasites. In this study, in vitro tests of the infusion in MCF7 cells showed high IC\n                    <jats:sub>50<\/jats:sub>\n                    values (&gt;200\u2005\u03bc\n                    <jats:sc>M<\/jats:sc>\n                    ). The combination of artemisinin and 3\u2010caffeoylquinic acid (3CA), two major components in the extract, was strongly antagonistic and gave a near total loss of cytotoxicity for artemisinin. We observed that the interaction of 3CAs with another cytotoxic compound, cisplatin, showed potentiation of activity by 2.5\u2010fold. The chelation of cellular iron by 3CA is hypothesized as a possible explanation for the loss of artemisinin activity.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.201402285","type":"journal-article","created":{"date-parts":[[2014,9,10]],"date-time":"2014-09-10T16:27:37Z","timestamp":1410366457000},"page":"2791-2797","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Comparative Cytotoxicity of Artemisinin and Cisplatin and Their Interactions with Chlorogenic Acids in MCF7 Breast Cancer Cells"],"prefix":"10.1002","volume":"9","author":[{"given":"John O.","family":"Suberu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isolda","family":"Romero\u2010Canel\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexei A.","family":"Lapkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy C.","family":"Barker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,10]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"e_1_2_6_2_2","unstructured":"\u00a0"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2009.01.017"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1250186"},{"key":"e_1_2_6_5_2","unstructured":"\u00a0"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-010-1355-4"},{"key":"e_1_2_6_7_2","first-page":"2277","volume":"24","author":"Singh N. 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