{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:46:51Z","timestamp":1791830811760,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T00:00:00Z","timestamp":1409875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In an attempt to discover a new generation of triazole antifungal agents, a series of triazole\u2013thiazolidinedione hybrids were designed and synthesized by molecular hybridization of the antifungal agent fluconazole and rosiglitazone (an antidiabetic). Most of the target compounds showed good to excellent inhibitory activity against a variety of clinically important fungal pathogens. In particular, compounds (\n                    <jats:italic>Z<\/jats:italic>\n                    )\u20105\u2010(2,4\u2010dichlorobenzylidene)\u20103\u2010(2\u2010(2,4\u2010difluorophenyl)\u20102\u2010hydroxy\u20103\u2010(1\n                    <jats:italic>H<\/jats:italic>\n                    \u20101,2,4\u2010triazol\u20101\u2010yl)propyl)thiazolidine\u20102,4\u2010dione) (\n                    <jats:bold>15\u2009c<\/jats:bold>\n                    ), (\n                    <jats:italic>Z<\/jats:italic>\n                    )\u20103\u2010(2\u2010(2,4\u2010difluorophenyl)\u20102\u2010hydroxy\u20103\u2010(1\n                    <jats:italic>H<\/jats:italic>\n                    \u20101,2,4\u2010triazol\u20101\u2010yl)propyl)\u20105\u2010(furan\u20103\u2010ylmethylene)thiazolidine\u20102,4\u2010dione (\n                    <jats:bold>15\u2009j<\/jats:bold>\n                    ), and (\n                    <jats:italic>Z<\/jats:italic>\n                    )\u20103\u2010(2\u2010(2,4\u2010difluorophenyl)\u20102\u2010hydroxy\u20103\u2010(1\n                    <jats:italic>H<\/jats:italic>\n                    \u20101,2,4\u2010triazol\u20101\u2010yl)propyl)\u20105\u2010(furan\u20103\u2010ylmethylene)thiazolidine\u20102,4\u2010dione (\n                    <jats:bold>15\u2009r<\/jats:bold>\n                    ) were highly active against\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    , with MIC\n                    <jats:sub>80<\/jats:sub>\n                    values in the range of 0.03\u20130.15\u2005\u03bc\n                    <jats:sc>M<\/jats:sc>\n                    . Moreover, compounds\n                    <jats:bold>15\u2009j<\/jats:bold>\n                    and\n                    <jats:bold>15\u2009r<\/jats:bold>\n                    were found to be effective against four fluconazole\u2010resistant clinical isolates; these two compounds are particularly promising antifungal leads for further optimization. Molecular docking studies revealed that the hydrogen bonding interactions between thiazolidinedione and CYP51 from\n                    <jats:italic>C.\u2005albicans<\/jats:italic>\n                    are important for antifungal activity. This study also demonstrates the effectiveness of molecular hybridization in antifungal drug discovery.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.201402320","type":"journal-article","created":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T07:31:09Z","timestamp":1409902269000},"page":"2639-2646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["From Antidiabetic to Antifungal: Discovery of Highly Potent Triazole\u2013Thiazolidinedione Hybrids as Novel Antifungal Agents"],"prefix":"10.1002","volume":"9","author":[{"given":"Shanchao","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengzheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqiang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhong","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyuan","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wannian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunquan","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,5]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46548-0"},{"key":"e_1_2_6_2_2","unstructured":"\u00a0"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-007-0595-7"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328322ffac"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/421946"},{"key":"e_1_2_6_6_2","unstructured":"\u00a0"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1130-1406(05)70048-6"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(03)00117-3"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.2165\/11596540-000000000-00000"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.11.001"},{"key":"e_1_2_6_11_2","unstructured":"\u00a0"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201100262"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201000530"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2010.503607"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2009.08.089"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.11.101"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/ml300429p"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S58680"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm4016284"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1586\/eri.10.163"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2010.06.006"},{"key":"e_1_2_6_22_2","unstructured":"\u00a0"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01630-08"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.200900468"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2004.10506984"},{"key":"e_1_2_6_26_2","unstructured":"\u00a0"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00894-009-0527-9"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm051211n"},{"key":"e_1_2_6_29_2","unstructured":"\u00a0"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2009.05.018"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2013.04.025"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2011.03.019"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2011.01138.x"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2009.07.144"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.200900103"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.09.070"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.03.014"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1039\/c1md00103e"},{"key":"e_1_2_6_39_2","un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