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They were also tested as inhibitors of lysosomal \u03b2\u2010 and \u03b1\u2010galactosidases in order to find new potent and selective pharmacological chaperones for treatment of the lysosomal storage disorder, Krabbe disease. Whereas 1\u2010<jats:italic>C<\/jats:italic>\u2010alkyl imino\u2010<jats:sc>L<\/jats:sc>\u2010arabinitols are totally inactive toward the three enzymes, 1\u2010<jats:italic>C<\/jats:italic>\u2010alkyl imino\u2010<jats:sc>D<\/jats:sc>\u2010galactitols were found to be active only toward \u03b1\u2010galactosidase\u2005A. Finally, 1\u2010<jats:italic>N<\/jats:italic>\u2010iminosugars provided the best results, as 4\u2010epi\u2010isofagomine was found to be a good inhibitor of both lysosomal \u03b2\u2010galactosidase and GALC. 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