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However, it is insoluble in water and displays poor oral bioavailability as a result of low absorption. New derivatives of curcumin were prepared by esterification of one or two of its phenolic groups with 1,1\u2032,2\u2010tris\u2010norsqualenic acid. These \u201csqualenoylcurcumins\u201d were formulated as water\u2010dispersible nanoassemblies of homogeneous size, and they proved to be stable. Squalenoylcurcumins were inactive against <jats:italic>Trypanosoma brucei brucei<\/jats:italic> trypomastigotes, even as nanoassemblies, in contrast with curcumin. However, against <jats:italic>Leishmania donovani<\/jats:italic> promastigotes, the activities of the squalenoylcurcumins and their nanoassemblies were enhanced relative to that of curcumin. In <jats:italic>L.\u2005donovani<\/jats:italic> axenic and intramacrophagic amastigotes, they showed activity in the range of miltefosine, with good selectivity indexes. 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