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We have discovered that gallic acid, a plant\u2010derived phytochemical, dramatically potentiates the antibacterial activities of several halogenated quinolines (up to 11\u2009800\u2010fold potentiation against <jats:italic>Staphylococcus aureus<\/jats:italic>) against pathogenic bacteria, including drug\u2010resistant clinical isolates. <jats:italic>S.\u2005aureus<\/jats:italic> demonstrated the highest sensitivity towards gallic acid\u2013halogenated quinoline combinations, including one halogenated quinoline that demonstrated potentiation of biofilm eradication activity against a methicillin\u2010resistant <jats:italic>S.\u2005aureus<\/jats:italic> (MRSA) clinical isolate. During our studies, we also demonstrated that these halogenated quionlines operate through an interesting metal(II) cation\u2010dependent mechanism and display promising mammalian cytotoxicity.<\/jats:p>","DOI":"10.1002\/cmdc.201500179","type":"journal-article","created":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T14:54:11Z","timestamp":1431701651000},"page":"1157-1162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A Phytochemical\u2013Halogenated Quinoline Combination Therapy Strategy for the Treatment of Pathogenic Bacteria"],"prefix":"10.1002","volume":"10","author":[{"given":"Yasmeen","family":"Abouelhassan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron T.","family":"Garrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"IV","given":"Verrill M.","family":"Norwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minh Thu","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shouguang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Robert W.","family":"Huigens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,15]]},"reference":[{"key":"e_1_2_3_1_2","unstructured":"Antimicrobial Resistance: Global Report on Surveillance 2014 World Health Organization Geneva Switzerland April2014 257\u2005pp. ISBN: 978\u201092\u20104\u2010156474\u20108; available viawww.who.int\/drugresistance\/documents\/surveillancereport\/."},{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2201"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3975"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2007.24"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.559"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2011.08.003"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2012.07.005"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.09.009"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.2.810-812.2006"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf303177p"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2012.0244"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/08927014.2013.845878"},{"key":"e_1_2_3_13_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1289657"},{"key":"e_1_2_3_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00350a069"},{"key":"e_1_2_3_15_2","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/953692"},{"key":"e_1_2_3_16_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA08728C"},{"key":"e_1_2_3_17_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S49763"},{"key":"e_1_2_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01484-12"},{"key":"e_1_2_3_19_2","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1128\/am.11.1.62-65.1963","volume":"11","author":"Gershon H.","year":"1963","journal-title":"Appl. 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