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Anthelminthic drugs are commonly used to treat the infection; however, vaccination is a more favorable strategy to combat this parasite. We designed new B\u2010cell peptide epitopes based on the aspartic protease of <jats:italic>N.\u2005americanus<\/jats:italic> (<jats:italic>Na<\/jats:italic>\u2010APR\u20101). The peptides were conjugated to self\u2010adjuvanting lipid core peptide (LCP) systems via stepwise solid\u2010phase peptide synthesis (SPPS) and copper catalyst azide\u2013alkyne cycloaddition (CuAAC) reactions. The LCP vaccine candidates were able to self\u2010assemble into nanoparticles, were administered to mice without the use of additional adjuvant, and generated antibodies that recognized the parent epitope. However, only one LCP derivative was able to produce a high titer of antibodies specific to <jats:italic>Na<\/jats:italic>\u2010APR\u20101; circular dichroism analyses of this compound showed a \u03b2\u2010sheet conformation for the incorporated epitope. This study provides important insight in epitope and delivery system design for the development of a vaccine against hookworm infections.<\/jats:p>","DOI":"10.1002\/cmdc.201500227","type":"journal-article","created":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T07:38:38Z","timestamp":1439451518000},"page":"1647-1654","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Lipopeptide Nanoparticles: Development of Vaccines against Hookworm Parasite"],"prefix":"10.1002","volume":"10","author":[{"given":"Abdullah A. H. 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