{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:51:25Z","timestamp":1791528685368,"version":"4.3.4"},"reference-count":202,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,8,20]],"date-time":"2015-08-20T00:00:00Z","timestamp":1440028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Science and Technology (DST) of the Government of India","award":["SR\/S2\/RJN-43\/2009"],"award-info":[{"award-number":["SR\/S2\/RJN-43\/2009"]}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Infectious diseases continue to be one of the major contributors to human morbidity. The rapid rate at which pathogenic microorganisms have developed resistance against frontline antimicrobials has compelled scientists to look for new alternatives. Given their vast antimicrobial repertoire, substantial research effort has been dedicated toward the development of antimicrobial peptides (AMPs) as alternative drugs. However, inherent limitations of AMPs have driven substantial efforts worldwide to develop synthetic mimics of AMPs. This review focuses on the progress that has been made toward the development of small molecules that emulate the properties of AMPs, both in terms of design and biological activity. Herein we provide an extensive discussion of the structural features of various designs and we examine biological properties that have been exploited. Furthermore, we raise a number of questions for which the field has yet to provide solutions and discuss possible future research directions that remain either unexploited or underexploited.<\/jats:p>","DOI":"10.1002\/cmdc.201500299","type":"journal-article","created":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T11:15:24Z","timestamp":1440760524000},"page":"1606-1624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":145,"title":["Membrane\u2010Active Small Molecules: Designs Inspired by Antimicrobial Peptides"],"prefix":"10.1002","volume":"10","author":[{"given":"Chandradhish","family":"Ghosh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayanta","family":"Haldar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,20]]},"reference":[{"key":"e_1_2_7_1_2","unstructured":"Antimicrobial Resistance: Global Report on Surveillance 2014 World Health Organization:www.who.int\/drugresistance\/documents\/surveillancereport\/en\/(accessed August 2015)."},{"key":"e_1_2_7_2_2","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1093\/cid\/cit152","volume":"56","author":"Boucher H. W.","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"e_1_2_7_3_2","unstructured":"\u00a0"},{"key":"e_1_2_7_4_2","unstructured":"Information and Resources on the Government\u2019s Plans to Slow the Growth of Antimicrobial Resistance UK Department of Health Public Health England Department for Environment Food & Rural Affairs and Veterinary Medicines Directorate:www.gov.uk\/government\/collections\/antimicrobial\u2010resistance\u2010amr\u2010information\u2010and\u2010resources(accessed August 2015);"},{"key":"e_1_2_7_5_2","unstructured":"National Action Plan for Combating Antibiotic\u2010Resistant Bacteria March 2015 US Government White House Office of the Press Secretary:www.whitehouse.gov\/the\u2010press\u2010office\/2015\/03\/27\/fact\u2010sheet\u2010obama\u2010administration\u2010releases\u2010national\u2010action\u2010plan\u2010combat\u2010ant(accessed August 2015)."},{"key":"e_1_2_7_6_2","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.bcp.2005.10.010","volume":"71","author":"Pel\u00e1ez F.","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"e_1_2_7_7_2","unstructured":"\u00a0"},{"key":"e_1_2_7_8_2","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/485439a","volume":"485","author":"Lewis K.","year":"2012","journal-title":"Nature"},{"key":"e_1_2_7_9_2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nrd3975","volume":"12","author":"Lewis K.","year":"2013","journal-title":"Nat. Rev. Drug Discovery"},{"key":"e_1_2_7_10_2","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1126\/science.1070633","volume":"296","author":"Kaeberlein T.","year":"2002","journal-title":"Science"},{"key":"e_1_2_7_11_2","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1128\/AEM.01754-09","volume":"76","author":"Nichols D.","year":"2010","journal-title":"Appl. Environ. Microb."},{"key":"e_1_2_7_12_2","unstructured":"\u00a0"},{"key":"e_1_2_7_13_2","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.chembiol.2014.01.014","volume":"21","author":"Gavrish E.","year":"2014","journal-title":"Chem. Biol."},{"key":"e_1_2_7_14_2","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature14098","volume":"517","author":"Ling L. L.","year":"2015","journal-title":"Nature"},{"key":"e_1_2_7_15_2","unstructured":"\u00a0"},{"key":"e_1_2_7_16_2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2174\/157340911793743538","volume":"7","author":"Goo K. S.","year":"2011","journal-title":"Curr. Comput.\u2010Aided Drug Des."},{"key":"e_1_2_7_17_2","doi-asserted-by":"crossref","first-page":"1003732","DOI":"10.1371\/journal.ppat.1003732","volume":"9","author":"Varney K. M.","year":"2013","journal-title":"PLoS Pathog."},{"key":"e_1_2_7_18_2","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/bit.25019","volume":"111","author":"Scanlon T. C.","year":"2014","journal-title":"Biotechnol. Bioeng."},{"key":"e_1_2_7_19_2","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/psc.908","volume":"14","author":"Jenssen H.","year":"2008","journal-title":"J. Pept. Sci."},{"key":"e_1_2_7_20_2","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/ja.2013.86","volume":"66","author":"Butler M. S.","year":"2013","journal-title":"J. Antibiot."},{"key":"e_1_2_7_21_2","unstructured":"\u00a0"},{"key":"e_1_2_7_22_2","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.1021\/jm500270w","volume":"57","author":"Yarlagadda V.","year":"2014","journal-title":"J. Med. Chem."},{"key":"e_1_2_7_23_2","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/ja.2014.144","volume":"68","author":"Yarlagadda V.","year":"2015","journal-title":"J. Antibiot."},{"key":"e_1_2_7_24_2","unstructured":"\u00a0"},{"key":"e_1_2_7_25_2","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/415389a","volume":"415","author":"Zasloff M.","year":"2002","journal-title":"Nature"},{"key":"e_1_2_7_26_2","unstructured":"Department of Pathology and Microbiology University of Nebraska Medical Center:aps.unmc.edu\/AP\/main.php."},{"key":"e_1_2_7_27_2","unstructured":"\u00a0"},{"key":"e_1_2_7_28_2","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nrmicro1098","volume":"3","author":"Brogden K. A.","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"e_1_2_7_29_2","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1038\/nbt1267","volume":"24","author":"Hancock R. E. W.","year":"2006","journal-title":"Nat. Biotechnol."},{"key":"e_1_2_7_30_2","unstructured":"\u00a0"},{"key":"e_1_2_7_31_2","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.peptides.2003.08.023","volume":"24","author":"Powers J. P.","year":"2003","journal-title":"Peptides"},{"key":"e_1_2_7_32_2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/bip.22076","volume":"98","author":"Alba A.","year":"2012","journal-title":"Biopolymers"},{"key":"e_1_2_7_33_2","unstructured":"\u00a0"},{"key":"e_1_2_7_34_2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1124\/pr.55.1.2","volume":"55","author":"Yeaman M. R.","year":"2003","journal-title":"Pharmacol. Rev."},{"key":"e_1_2_7_35_2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0005-2736(99)00200-X","volume":"1462","author":"Shai Y.","year":"1999","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"e_1_2_7_36_2","unstructured":"\u00a0"},{"key":"e_1_2_7_37_2","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.biochi.2005.04.012","volume":"87","author":"Marquez B.","year":"2005","journal-title":"Biochimie"},{"key":"e_1_2_7_38_2","doi-asserted-by":"crossref","first-page":"5853","DOI":"10.1128\/jb.178.20.5853-5859.1996","volume":"178","author":"Nikaido H.","year":"1996","journal-title":"J. Bacteriol."},{"key":"e_1_2_7_39_2","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1128\/CMR.00037-09","volume":"23","author":"Drawz S. M.","year":"2010","journal-title":"Clin. Microbiol. Rev."},{"key":"e_1_2_7_40_2","first-page":"11","volume":"8","author":"Nizet V.","year":"2006","journal-title":"Curr. Issues Mol. Biol."},{"key":"e_1_2_7_41_2","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.tibtech.2009.07.004","volume":"27","author":"Easton D. M.","year":"2009","journal-title":"Trends Biotechnol."},{"key":"e_1_2_7_42_2","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/nchembio.1393","volume":"9","author":"Hilchie A. L.","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"e_1_2_7_43_2","unstructured":"\u00a0"},{"key":"e_1_2_7_44_2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nrd3591","volume":"11","author":"Fjell C. D.","year":"2011","journal-title":"Nat. Rev. Drug Discovery"},{"key":"e_1_2_7_45_2","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nbt.2572","volume":"31","author":"Fox J. L.","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"e_1_2_7_46_2","unstructured":"\u00a0"},{"key":"e_1_2_7_47_2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.nantod.2012.04.003","volume":"7","author":"Engler A. C.","year":"2012","journal-title":"Nano Today"},{"key":"e_1_2_7_48_2","doi-asserted-by":"crossref","first-page":"5449","DOI":"10.1073\/pnas.84.15.5449","volume":"84","author":"Zasloff M.","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_2_7_49_2","doi-asserted-by":"crossref","first-page":"9389","DOI":"10.1039\/c3cc43751e","volume":"49","author":"Uppu D. S. S. M.","year":"2013","journal-title":"Chem. Commun."},{"key":"e_1_2_7_50_2","unstructured":"\u00a0"},{"key":"e_1_2_7_51_2","doi-asserted-by":"crossref","first-page":"4128","DOI":"10.1021\/ja044205+","volume":"127","author":"Kuroda K.","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"e_1_2_7_52_2","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1002\/anie.200702287","volume":"47","author":"Sambhy V.","year":"2008","journal-title":"Angew. Chem. Int. Ed."},{"key":"e_1_2_7_52_3","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/ange.200702287","volume":"120","year":"2008","journal-title":"Angew. Chem."},{"key":"e_1_2_7_53_2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/chem.200801233","volume":"15","author":"Gabriel G. J.","year":"2009","journal-title":"Chem. Eur. J."},{"key":"e_1_2_7_54_2","doi-asserted-by":"crossref","first-page":"15474","DOI":"10.1021\/ja077288d","volume":"129","author":"Mowery B. P.","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"e_1_2_7_55_2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1021\/bm900896h","volume":"11","author":"Zhou C. C.","year":"2010","journal-title":"Biomacromolecules"},{"key":"e_1_2_7_56_2","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nchem.1012","volume":"3","author":"Nederberg F.","year":"2011","journal-title":"Nat. Chem."},{"key":"e_1_2_7_57_2","doi-asserted-by":"crossref","first-page":"15870","DOI":"10.1021\/ja045664d","volume":"126","author":"Ilker M. F.","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"e_1_2_7_58_2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1021\/bk-2007-0980.ch011","volume":"980","author":"Ilker M. F.","year":"2007","journal-title":"ACS Symp. Ser."},{"key":"e_1_2_7_59_2","doi-asserted-by":"crossref","first-page":"17667","DOI":"10.1073\/pnas.0608803103","volume":"103","author":"Haldar J.","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_2_7_60_2","unstructured":"\u00a0"},{"key":"e_1_2_7_61_2","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1021\/mp5004724","volume":"12","author":"Nadithe V.","year":"2015","journal-title":"Mol. Pharmaceutics"},{"key":"e_1_2_7_62_2","doi-asserted-by":"crossref","first-page":"4333","DOI":"10.1021\/ja500036r","volume":"136","author":"Liu R. H.","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"e_1_2_7_63_2","first-page":"0119422","volume":"10","author":"Uppu D. S.","year":"2015","journal-title":"PLoS One"},{"key":"e_1_2_7_64_2","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1021\/ja512567y","volume":"137","author":"Liu R.","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"e_1_2_7_65_2","unstructured":"\u00a0"},{"key":"e_1_2_7_66_2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/wnan.1199","volume":"5","author":"Kuroda K.","year":"2013","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"e_1_2_7_67_2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/12_2010_85","volume":"251","author":"Lienkamp K.","year":"2010","journal-title":"Adv. Polym. Sci."},{"key":"e_1_2_7_68_2","doi-asserted-by":"crossref","first-page":"11784","DOI":"10.1002\/chem.200900049","volume":"15","author":"Lienkamp K.","year":"2009","journal-title":"Chem. Eur. J."},{"key":"e_1_2_7_69_2","unstructured":"\u00a0"},{"key":"e_1_2_7_70_2","doi-asserted-by":"crossref","first-page":"12316","DOI":"10.1074\/jbc.M413406200","volume":"280","author":"Chen Y. X.","year":"2005","journal-title":"J. Biol. Chem."},{"key":"e_1_2_7_71_2","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1016\/S0006-3495(03)75103-0","volume":"84","author":"Chen F. Y.","year":"2003","journal-title":"Biophys. J."},{"key":"e_1_2_7_72_2","unstructured":"\u00a0"},{"key":"e_1_2_7_73_2","doi-asserted-by":"crossref","first-page":"7553","DOI":"10.1021\/ja0107475","volume":"123","author":"Liu D.","year":"2001","journal-title":"J. Am. Chem. Soc."},{"key":"e_1_2_7_74_2","first-page":"298","volume":"405","author":"Porter E. A.","year":"2000","journal-title":"Nature"},{"key":"e_1_2_7_75_2","unstructured":"\u00a0"},{"key":"e_1_2_7_76_2","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1021\/ja044392b","volume":"127","author":"Violette A.","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"e_1_2_7_77_2","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.chembiol.2006.03.009","volume":"13","author":"Violette A.","year":"2006","journal-title":"Chem. Biol."},{"key":"e_1_2_7_78_2","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1073\/pnas.0708254105","volume":"105","author":"Chongsiriwatana N. P.","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_2_7_79_2","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nbt1309","volume":"25","author":"Radzishevsky I. S.","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"e_1_2_7_80_2","doi-asserted-by":"crossref","first-page":"9729","DOI":"10.1039\/c1cc13684d","volume":"47","author":"Padhee S.","year":"2011","journal-title":"Chem. Commun."},{"key":"e_1_2_7_81_2","unstructured":"\u00a0"},{"key":"e_1_2_7_82_2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/bip.20970","volume":"90","author":"Som A.","year":"2008","journal-title":"Biopolymers"},{"key":"e_1_2_7_83_2","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1007\/s00018-011-0717-3","volume":"68","author":"Giuliani A.","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"e_1_2_7_84_2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3389\/fimmu.2012.00171","volume":"3","author":"Scorciapino M. A.","year":"2012","journal-title":"Front. Immunol."},{"key":"e_1_2_7_85_2","doi-asserted-by":"crossref","first-page":"5110","DOI":"10.1073\/pnas.082046199","volume":"99","author":"Tew G. N.","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_2_7_86_2","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1002\/anie.200352791","volume":"43","author":"Liu D. H.","year":"2004","journal-title":"Angew. Chem. Int. Ed."},{"key":"e_1_2_7_86_3","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1002\/ange.200352791","volume":"116","year":"2004","journal-title":"Angew. Chem."},{"key":"e_1_2_7_87_2","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1039\/b413679a","author":"Tang H.","year":"2005","journal-title":"Chem. Commun."},{"key":"e_1_2_7_88_2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.chembiol.2006.02.007","volume":"13","author":"Tang H.","year":"2006","journal-title":"Chem. Biol."},{"key":"e_1_2_7_89_2","doi-asserted-by":"crossref","first-page":"6968","DOI":"10.1073\/pnas.0811818106","volume":"106","author":"Choi S.","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_2_7_90_2","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1021\/jm101410t","volume":"54","author":"Thaker H. D.","year":"2011","journal-title":"J. Med. Chem."},{"key":"e_1_2_7_91_2","unstructured":"\u00a0"},{"key":"e_1_2_7_92_2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/pat.565","volume":"16","author":"Arnt L.","year":"2005","journal-title":"Polym. Adv. Technol."},{"key":"e_1_2_7_93_2","first-page":"982","volume":"229","author":"Tew G. N.","year":"2005","journal-title":"Abstr. Pap. Am. Chem. Soc."},{"key":"e_1_2_7_94_2","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.1002\/pola.20304","volume":"42","author":"Arnt L.","year":"2004","journal-title":"J. Polym. Sci. Part A"},{"key":"e_1_2_7_95_2","doi-asserted-by":"crossref","first-page":"13123","DOI":"10.1021\/ja061186q","volume":"128","author":"Ishitsuka Y.","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"e_1_2_7_96_2","doi-asserted-by":"crossref","first-page":"11088","DOI":"10.1021\/ja303304j","volume":"134","author":"Thaker H. D.","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"e_1_2_7_97_2","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1021\/ml300307b","volume":"4","author":"Thaker H. D.","year":"2013","journal-title":"ACS Med. Chem. Lett."},{"key":"e_1_2_7_98_2","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1021\/ml400155a","volume":"4","author":"Fu T. H.","year":"2013","journal-title":"ACS Med. Chem. Lett."},{"key":"e_1_2_7_99_2","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1021\/jm0340039","volume":"46","author":"Str\u00f8m M. B.","year":"2003","journal-title":"J. Med. Chem."},{"key":"e_1_2_7_100_2","unstructured":"\u00a0"},{"key":"e_1_2_7_101_2","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1021\/jm049582b","volume":"47","author":"Haug B. E.","year":"2004","journal-title":"J. Med. Chem."},{"key":"e_1_2_7_102_2","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/psc.338","volume":"7","author":"Haug B. E.","year":"2001","journal-title":"J. Pept. Sci."},{"key":"e_1_2_7_103_2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/psc.404","volume":"8","author":"Haug B. E.","year":"2002","journal-title":"J. Pept. Sci."},{"key":"e_1_2_7_104_2","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/psc.398","volume":"8","author":"Str\u00f8m M. B.","year":"2002","journal-title":"J. Pept. Sci."},{"key":"e_1_2_7_105_2","doi-asserted-by":"crossref","first-page":"4306","DOI":"10.1021\/jm701600a","volume":"51","author":"Haug B. E.","year":"2008","journal-title":"J. Med. Chem."},{"key":"e_1_2_7_106_2","doi-asserted-by":"crossref","first-page":"5786","DOI":"10.1021\/jm200450h","volume":"54","author":"Isaksson J.","year":"2011","journal-title":"J. Med. Chem."},{"key":"e_1_2_7_107_2","unstructured":"\u00a0"},{"key":"e_1_2_7_108_2","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1016\/j.bmc.2010.02.033","volume":"18","author":"Bremner J. B.","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"e_1_2_7_109_2","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.1016\/j.bmc.2010.05.005","volume":"18","author":"Bremner J. B.","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"e_1_2_7_110_2","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1016\/j.bmc.2011.04.013","volume":"19","author":"Coghlan D. R.","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"e_1_2_7_111_2","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1016\/j.bmcl.2009.04.046","volume":"19","author":"Garas A.","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"e_1_2_7_112_2","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.bmc.2005.09.019","volume":"14","author":"Samosorn S.","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"e_1_2_7_113_2","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/anie.200904392","volume":"49","author":"Bremner J. B.","year":"2010","journal-title":"Angew. Chem. Int. Ed."},{"key":"e_1_2_7_113_3","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/ange.200904392","volume":"122","year":"2010","journal-title":"Angew. Chem."},{"key":"e_1_2_7_114_2","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.bbamem.2008.10.020","volume":"1788","author":"Rotem S.","year":"2009","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"e_1_2_7_115_2","unstructured":"\u00a0"},{"key":"e_1_2_7_116_2","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.chembiol.2008.03.006","volume":"15","author":"Radzishevsky I. S.","year":"2008","journal-title":"Chem. Biol."},{"key":"e_1_2_7_117_2","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.1128\/AAC.00656-08","volume":"52","author":"Sarig H.","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_2_7_118_2","doi-asserted-by":"crossref","first-page":"80025","DOI":"10.1371\/journal.pone.0080025","volume":"8","author":"Murugan R. N.","year":"2013","journal-title":"PLoS One"},{"key":"e_1_2_7_119_2","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1021\/jm301683j","volume":"56","author":"Zou H. X.","year":"2013","journal-title":"J. Med. Chem."},{"key":"e_1_2_7_120_2","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1021\/jm501285x","volume":"58","author":"Koh J. J.","year":"2015","journal-title":"J. Med. Chem."},{"key":"e_1_2_7_121_2","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1021\/jm401680a","volume":"57","author":"Ghosh C.","year":"2014","journal-title":"J. Med. Chem."},{"key":"e_1_2_7_122_2","doi-asserted-by":"crossref","first-page":"9409","DOI":"10.1021\/jm5013566","volume":"57","author":"Konai M. M.","year":"2014","journal-title":"J. Med. Chem."},{"key":"e_1_2_7_123_2","unstructured":"\u00a0"},{"key":"e_1_2_7_124_2","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1021\/ja973881r","volume":"120","author":"Li C. H.","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"e_1_2_7_125_2","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1128\/AAC.43.6.1347","volume":"43","author":"Li C.","year":"1999","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_2_7_126_2","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1021\/ar700270t","volume":"41","author":"Lai X. Z.","year":"2008","journal-title":"Acc. Chem. Res."},{"key":"e_1_2_7_127_2","doi-asserted-by":"crossref","first-page":"5020","DOI":"10.1021\/jm900519b","volume":"52","author":"Vooturi S. K.","year":"2009","journal-title":"J. Med. Chem."},{"key":"e_1_2_7_128_2","doi-asserted-by":"crossref","first-page":"6367","DOI":"10.1039\/c1ob05643c","volume":"9","author":"Vooturi S. K.","year":"2011","journal-title":"Org. Biomol. Chem."},{"key":"e_1_2_7_129_2","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1021\/jm901052r","volume":"53","author":"Hansen T.","year":"2010","journal-title":"J. Med. Chem."},{"key":"e_1_2_7_130_2","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1021\/jm101327d","volume":"54","author":"Hansen T.","year":"2011","journal-title":"J. Med. Chem."},{"key":"e_1_2_7_131_2","unstructured":"\u00a0"},{"key":"e_1_2_7_132_2","doi-asserted-by":"crossref","first-page":"12225","DOI":"10.1021\/la302303d","volume":"28","author":"Hoque J.","year":"2012","journal-title":"Langmuir"},{"key":"e_1_2_7_133_2","first-page":"58","author":"Hoque J.","year":"2015","journal-title":"J. Med. Chem."},{"key":"e_1_2_7_134_2","unstructured":"\u00a0"},{"key":"e_1_2_7_135_2","doi-asserted-by":"crossref","first-page":"8462","DOI":"10.1002\/anie.201003104","volume":"49","author":"Ivankin A.","year":"2010","journal-title":"Angew. Chem. Int. Ed."},{"key":"e_1_2_7_135_3","doi-asserted-by":"crossref","first-page":"8640","DOI":"10.1002\/ange.201003104","volume":"122","year":"2010","journal-title":"Angew. Chem."},{"key":"e_1_2_7_136_2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1021\/ar900036b","volume":"43","author":"Tew G. N.","year":"2010","journal-title":"Acc. Chem. Res."},{"key":"e_1_2_7_137_2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1086\/655995","volume":"31","author":"Rice L. B.","year":"2010","journal-title":"Infect. Cont. Hosp. Ep."},{"key":"e_1_2_7_138_2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1128\/AAC.03513-14","volume":"59","author":"Nilsson A. C.","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_2_7_139_2","unstructured":"\u00a0"},{"key":"e_1_2_7_140_2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0005-2736(99)00205-9","volume":"1462","author":"Bechinger B.","year":"1999","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"e_1_2_7_141_2","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1002\/pro.5560021208","volume":"2","author":"Bechinger B.","year":"1993","journal-title":"Protein Sci."},{"key":"e_1_2_7_142_2","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1016\/S0006-3495(01)75868-7","volume":"81","author":"Yamaguchi S.","year":"2001","journal-title":"Biophys. J."},{"key":"e_1_2_7_143_2","unstructured":"\u00a0"},{"key":"e_1_2_7_144_2","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.1021\/bi036153r","volume":"43","author":"Lee M. T.","year":"2004","journal-title":"Biochemistry"},{"key":"e_1_2_7_145_2","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0006-3495(90)82599-6","volume":"57","author":"Wu Y.","year":"1990","journal-title":"Biophys. J."},{"key":"e_1_2_7_146_2","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/S0006-3495(97)78713-7","volume":"72","author":"Ladokhin A. S.","year":"1997","journal-title":"Biophys. J."},{"key":"e_1_2_7_147_2","unstructured":"\u00a0"},{"key":"e_1_2_7_148_2","doi-asserted-by":"crossref","first-page":"15614","DOI":"10.1021\/bi00048a002","volume":"34","author":"He K.","year":"1995","journal-title":"Biochemistry"},{"key":"e_1_2_7_149_2","doi-asserted-by":"crossref","first-page":"13723","DOI":"10.1021\/bi9620621","volume":"35","author":"Ludtke S. J.","year":"1996","journal-title":"Biochemistry"},{"key":"e_1_2_7_150_2","unstructured":"\u00a0"},{"key":"e_1_2_7_151_2","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/S0968-0004(00)89101-X","volume":"20","author":"Shai Y.","year":"1995","journal-title":"Trends Biochem. Sci."},{"key":"e_1_2_7_152_2","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/S0196-9781(01)00498-3","volume":"22","author":"Shai Y.","year":"2001","journal-title":"Peptides"},{"key":"e_1_2_7_153_2","doi-asserted-by":"crossref","first-page":"23769","DOI":"10.1016\/S0021-9258(18)54349-0","volume":"266","author":"Rapaport D.","year":"1991","journal-title":"J. Biol. Chem."},{"key":"e_1_2_7_154_2","unstructured":"\u00a0"},{"key":"e_1_2_7_155_2","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1016\/j.bpj.2011.02.018","volume":"100","author":"Lee C. C.","year":"2011","journal-title":"Biophys. J."},{"key":"e_1_2_7_156_2","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0006-3495(98)77554-X","volume":"75","author":"Yang L.","year":"1998","journal-title":"Biophys. J."},{"key":"e_1_2_7_157_2","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/S0006-3495(01)75802-X","volume":"81","author":"Yang L.","year":"2001","journal-title":"Biophys. J."},{"key":"e_1_2_7_158_2","unstructured":"\u00a0"},{"key":"e_1_2_7_159_2","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/(SICI)1097-0282(1998)47:6<451::AID-BIP4>3.0.CO;2-F","volume":"47","author":"Oren Z.","year":"1998","journal-title":"Biopolymers"},{"key":"e_1_2_7_160_2","doi-asserted-by":"crossref","first-page":"12416","DOI":"10.1021\/bi00164a017","volume":"31","author":"Pouny Y.","year":"1992","journal-title":"Biochemistry"},{"key":"e_1_2_7_161_2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.it.2008.12.003","volume":"30","author":"Lai Y.","year":"2009","journal-title":"Trends Immunol."},{"key":"e_1_2_7_162_2","unstructured":"\u00a0"},{"key":"e_1_2_7_163_2","doi-asserted-by":"crossref","first-page":"4076","DOI":"10.1021\/bi100378m","volume":"49","author":"Epand R. F.","year":"2010","journal-title":"Biochemistry"},{"key":"e_1_2_7_164_2","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1016\/j.bpj.2010.03.002","volume":"98","author":"Epand R. F.","year":"2010","journal-title":"Biophys. J."},{"key":"e_1_2_7_165_2","unstructured":"\u00a0"},{"key":"e_1_2_7_166_2","doi-asserted-by":"crossref","first-page":"7609","DOI":"10.1021\/ja8093247","volume":"131","author":"Rathinakumar R.","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"e_1_2_7_167_2","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1021\/cb1001558","volume":"5","author":"Wimley W. C.","year":"2010","journal-title":"ACS Chem. Biol."},{"key":"e_1_2_7_168_2","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1021\/bi00713a022","volume":"13","author":"Sims P. J.","year":"1974","journal-title":"Biochemistry"},{"key":"e_1_2_7_169_2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0167-7012(99)00048-2","volume":"37","author":"Boulos L.","year":"1999","journal-title":"J. Microbiol. Methods"},{"key":"e_1_2_7_170_2","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1128\/AAC.26.4.546","volume":"26","author":"Loh B.","year":"1984","journal-title":"Antimicrob. Agents Annu."},{"key":"e_1_2_7_171_2","doi-asserted-by":"crossref","first-page":"5043","DOI":"10.1128\/AAC.05009-11","volume":"55","author":"Mensa B.","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_2_7_172_2","doi-asserted-by":"crossref","first-page":"5136","DOI":"10.1128\/AAC.02955-14","volume":"58","author":"Mensa B.","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_2_7_173_2","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1073\/pnas.1319900111","volume":"111","author":"Wenzel M.","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_2_7_174_2","doi-asserted-by":"crossref","first-page":"4971","DOI":"10.1128\/AAC.00834-10","volume":"54","author":"Moffatt J. H.","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_2_7_175_2","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1128\/AAC.45.4.999-1007.2001","volume":"45","author":"Lewis K.","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_2_7_176_2","unstructured":"\u00a0"},{"key":"e_1_2_7_177_2","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrmicro2415","volume":"8","author":"Flemming H. C.","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"e_1_2_7_178_2","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1073\/pnas.1115006109","volume":"109","author":"Periasamy S.","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_2_7_179_2","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/mbo3.77","volume":"2","author":"Nagant C.","year":"2013","journal-title":"MicrobiologyOpen"},{"key":"e_1_2_7_180_2","doi-asserted-by":"crossref","first-page":"8641","DOI":"10.1016\/j.biomaterials.2012.08.003","volume":"33","author":"Williams D. L.","year":"2012","journal-title":"Biomaterials"},{"key":"e_1_2_7_181_2","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.1038\/jid.2009.120","volume":"129","author":"Howell M. D.","year":"2009","journal-title":"J. Invest. Dermatol."},{"key":"e_1_2_7_182_2","unstructured":"\u00a0"},{"key":"e_1_2_7_183_2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.ijid.2011.03.021","volume":"15","author":"Tiuman T. S.","year":"2011","journal-title":"Int. J. Infect. Dis."},{"key":"e_1_2_7_184_2","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1371\/journal.pntd.0001919","volume":"6","author":"Mitashi P.","year":"2012","journal-title":"PLoS Neglected Trop. Dis."},{"key":"e_1_2_7_185_2","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1186\/1475-2875-11-316","volume":"11","author":"Anthony M. P.","year":"2012","journal-title":"Malar. J."},{"key":"e_1_2_7_186_2","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1645\/GE-2329.1","volume":"96","author":"Lara D.","year":"2010","journal-title":"J. Parasitol."},{"key":"e_1_2_7_187_2","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.chom.2012.10.017","volume":"12","author":"Love M. S.","year":"2012","journal-title":"Cell Host Microbe"},{"key":"e_1_2_7_188_2","unstructured":"\u00a0"},{"key":"e_1_2_7_189_2","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/psc.704","volume":"11","author":"McPhee J. B.","year":"2005","journal-title":"J. Pept. Sci."},{"key":"e_1_2_7_190_2","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nrmicro2745","volume":"10","author":"Hancock R. E. W.","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"e_1_2_7_191_2","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1007\/s00018-007-6475-6","volume":"64","author":"Mookherjee N.","year":"2007","journal-title":"Cell. Mol. Life Sci."},{"key":"e_1_2_7_192_2","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.copbio.2008.10.006","volume":"19","author":"Hamill P.","year":"2008","journal-title":"Curr Opin Biotech"},{"key":"e_1_2_7_193_2","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/bip.22250","volume":"100","author":"Haney E. F.","year":"2013","journal-title":"Biopolymers"},{"key":"e_1_2_7_194_2","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1128\/CVI.00291-12","volume":"19","author":"Som A.","year":"2012","journal-title":"Clin. Vaccine Immunol."},{"key":"e_1_2_7_195_2","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nrmicro1557","volume":"5","author":"Lewis K.","year":"2007","journal-title":"Nat. Rev. Microbiol."},{"key":"e_1_2_7_196_2","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nrmicro2474","volume":"9","author":"Hurdle J. G.","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"e_1_2_7_197_2","doi-asserted-by":"crossref","first-page":"69483","DOI":"10.1371\/journal.pone.0069483","volume":"8","author":"Bojsen R.","year":"2013","journal-title":"PLoS One"},{"key":"e_1_2_7_198_2","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1021\/am507482y","volume":"7","author":"Hoque J.","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"}],"container-title":["ChemMedChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcmdc.201500299","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.201500299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T15:16:40Z","timestamp":1760282200000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cmdc.201500299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,20]]},"references-count":202,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1002\/cmdc.201500299"],"URL":"https:\/\/doi.org\/10.1002\/cmdc.201500299","archive":["Portico"],"relation":{},"ISSN":["1860-7179","1860-7187"],"issn-type":[{"value":"1860-7179","type":"print"},{"value":"1860-7187","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,20]]},"assertion":[{"value":"2015-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}