{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:43:21Z","timestamp":1761489801413,"version":"build-2065373602"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T00:00:00Z","timestamp":1444262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Research Foundation of South Africa"},{"DOI":"10.13039\/501100004477","name":"Stellenbosch University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004477","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>7\u2010Chloroquinoline\u2010based antimalarial drugs are effective in the inhibition of hemozoin formation in the food vacuole of the <jats:italic>Plasmodium<\/jats:italic> parasite, the causative agent of malaria. We synthesized five series of ferroquine (FQ) and phenylequine (PQ) derivatives, which display good in vitro efficacy toward both the chloroquine\u2010sensitive (CQS) NF54 (IC<jats:sub>50<\/jats:sub>: 4.2\u2005n<jats:sc>m<\/jats:sc>) and chloroquine\u2010resistant (CQR) Dd2 (IC<jats:sub>50<\/jats:sub>: 33.7\u2005n<jats:sc>m<\/jats:sc>) strains of <jats:italic>P.\u2005falciparum<\/jats:italic>. Several compounds were found to have good inhibitory activity against \u03b2\u2010hematin formation in an NP\u201040 detergent assay, with IC<jats:sub>50<\/jats:sub> values ranging between 10.4 and 19.2\u2005\u03bc<jats:sc>m<\/jats:sc>.<\/jats:p>","DOI":"10.1002\/cmdc.201500349","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T13:24:41Z","timestamp":1444310681000},"page":"2099-2110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Design, Synthesis, and Evaluation of Novel Ferroquine and Phenylequine Analogues as Potential Antiplasmodial Agents"],"prefix":"10.1002","volume":"10","author":[{"given":"Leon","family":"Jacobs","sequence":"first","affiliation":[{"name":"Department of Chemistry and Polymer Science Stellenbosch University  Private Bag X1 Matieland 7602 South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"de\u2005Kock","sequence":"additional","affiliation":[{"name":"Department of Pharmacology University of Cape Town  Private Bag X2 Rondebosch Cape Town 7700 South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine A.","family":"de\u2005Villiers","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Polymer Science Stellenbosch University  Private Bag X1 Matieland 7602 South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Pharmacology University of Cape Town  Private Bag X2 Rondebosch Cape Town 7700 South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent J.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Polymer Science Stellenbosch University  Private Bag X1 Matieland 7602 South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem A. L.","family":"van\u2005Otterlo","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Polymer Science Stellenbosch University  Private Bag X1 Matieland 7602 South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret A. L.","family":"Blackie","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Polymer Science Stellenbosch University  Private Bag X1 Matieland 7602 South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,8]]},"reference":[{"key":"e_1_2_6_1_1","unstructured":"World Malaria Report 2014 World Health Organization:http:\/\/www.who.int\/malaria\/publications\/world_malaria_report_2014\/en\/(accessed August 4 2015)."},{"key":"e_1_2_6_2_1","unstructured":"Malaria UNICEF 2014:http:\/\/www.unicef.org\/health\/index_malaria.html(accessed August 4 2015)."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1179\/146532810X12858955921032"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07937"},{"key":"e_1_2_6_5_1","first-page":"45","volume":"41","author":"Farooq U.","year":"2004","journal-title":"J. Vector Borne Dis."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16767-6"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1155165"},{"key":"e_1_2_6_8_1","unstructured":"Malaria Consortium 2015:http:\/\/www.malariaconsortium.org\/pages\/malaria.html(accessed August 4 2015)."},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314981"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-13-7"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/202805a0"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.2.325"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm990437l"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161213804070294"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(05)00077-8"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(93)90056-J"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm970401y"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp0500061"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05359-11"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/1439-7633(20020503)3:5<418::AID-CBIC418>3.0.CO;2-P"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2009.12.030"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm020858u"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/cc060110n"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2009.05.075"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)01036-4"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2007.07.012"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm980146x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/B303335J"},{"volume-title":"Purification of Laboratory Chemicals (3rd Ed.)","year":"1988","author":"Perrin D. D.","key":"e_1_2_6_29_1"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-328X(97)00143-5"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.781840"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1993.48.205"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.2174\/138620710790980496"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2005.04.013"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0108767307043930"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-7862(02)00030-8"}],"container-title":["ChemMedChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcmdc.201500349","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.201500349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T15:31:16Z","timestamp":1760283076000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cmdc.201500349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,8]]},"references-count":36,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1002\/cmdc.201500349"],"URL":"https:\/\/doi.org\/10.1002\/cmdc.201500349","archive":["Portico"],"relation":{},"ISSN":["1860-7179","1860-7187"],"issn-type":[{"type":"print","value":"1860-7179"},{"type":"electronic","value":"1860-7187"}],"subject":[],"published":{"date-parts":[[2015,10,8]]},"assertion":[{"value":"2015-08-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}