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Thanks to this protocol, we were able to identify a fragment that displays activity in the low\u2010micromolar range at both \u03b2\u2010secretase\u20051 (BACE\u20101) and glycogen synthase kinase\u20053\u03b2 (GSK\u20103\u03b2). These two structurally and physiologically unrelated enzymes likely contribute, through different pathways, to the onset of Alzheimer\u2032s disease (AD). Therefore, their simultaneous inhibition holds great potential in exerting a profound effect on AD. In perspective, the strategy outlined herein can be adapted to other target combinations.<\/jats:p>","DOI":"10.1002\/cmdc.201500521","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T12:03:02Z","timestamp":1449748982000},"page":"1259-1263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Development and Application of a Virtual Screening Protocol for the Identification of Multitarget Fragments"],"prefix":"10.1002","volume":"11","author":[{"given":"Giovanni","family":"Bottegoni","sequence":"first","affiliation":[{"name":"CompuNet Istituto Italiano di Tecnologia  16163 Genova Italy"},{"name":"BiKi Technologies srl  16121 Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Veronesi","sequence":"additional","affiliation":[{"name":"PharmaChemistry Facility Istituto Italiano di Tecnologia  16163 Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Bisignano","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Cardiovascular Research Institute University of California  San Francisco CA 94158 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puneet","family":"Kacker","sequence":"additional","affiliation":[{"name":"Drug Repurposing Division GVK Biosciences Pvt. 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