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To find potential NMO therapeutics, a screening system was established and used to identify inhibitors of NMO\u2010IgG\u2010mediated complement\u2010dependent cytotoxicity (CDC). The screening of approximately 400 compounds yielded potent hit compounds with inhibitory effects against CDC in U87\u2010MG cells expressing human AQP4. Derivatives of the hit compounds were synthesized and evaluated for their inhibition of CDC. Of the small molecules synthesized, (<jats:italic>E<\/jats:italic>)\u20101\u2010(2\u2010((4\u2010methoxyphenyl)sulfonyl)vinyl)\u2010[4\u2010[(3\u2010trifluoromethyl)phenyl] methoxy]benzene (<jats:bold>5\u2009c<\/jats:bold>) showed the most potent activity in both stably transfected U87\u2010MG cells and mice\u2010derived astrocytes. The results of this study suggest that <jats:bold>5\u2009c<\/jats:bold>, which targets NMO\u2010IgG\u2010specific CDC, may be useful as a research tool and a potential candidate for therapeutic development for the treatment of NMO.<\/jats:p>","DOI":"10.1002\/cmdc.201500546","type":"journal-article","created":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T04:06:42Z","timestamp":1453694802000},"page":"377-381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Screening, Synthesis, and In Vitro Evaluation of Vinyl Sulfones as Inhibitors of Complement\u2010Dependent Cytotoxicity in Neuromyelitis Optica"],"prefix":"10.1002","volume":"11","author":[{"given":"Eun Ji","family":"Ju","sequence":"first","affiliation":[{"name":"Center for Neuro-Medicine Korea Institute of Science and Technology  Seoul 02792 Republic of Korea"},{"name":"Department of Biotechnology Yonsei University  Seoul 03722 Republic of 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