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They protect G\u2010quadruplex DNA (G<jats:sub>4<\/jats:sub>\u2010DNA) against thermal denaturation and show <jats:italic>K<\/jats:italic><jats:sub>A<\/jats:sub> values in the range of 7.4\u00d710<jats:sup>5<\/jats:sup> to 4\u00d710<jats:sup>7<\/jats:sup>\u2009<jats:sc>m<\/jats:sc><jats:sup>\u22121<\/jats:sup> for G<jats:sub>4<\/jats:sub>\u2010DNA models. Complex <jats:bold>4<\/jats:bold> exhibits an IC<jats:sub>50<\/jats:sub> value of 70\u2005n<jats:sc>m<\/jats:sc> for telomerase inhibition.<\/jats:p>","DOI":"10.1002\/cmdc.201600171","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T12:24:02Z","timestamp":1462969442000},"page":"1133-1136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Efficient Inhibition of Telomerase by Nickel\u2013Salophen Complexes"],"prefix":"10.1002","volume":"11","author":[{"given":"Laureline","family":"Lecarme","sequence":"first","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes D\u00e9partement de Chimie Mol\u00e9culaire UMR-5250  38041 Grenoble Cedex\u20059 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enora","family":"Prado","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes D\u00e9partement de Chimie Mol\u00e9culaire UMR-5250  38041 Grenoble Cedex\u20059 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0868-3670","authenticated-orcid":false,"given":"Aurore","family":"De\u2005Rache","sequence":"additional","affiliation":[{"name":"ARNA laboratory Inserm U1212, CNRS UMR 5320 Institut Europ\u00e9en de Chimie et Biologie IECB \u2013 Universit\u00e9 de Bordeaux  2\u2005rue Robert Escarpit 33607 Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Laure","family":"Nicolau\u2010Travers","sequence":"additional","affiliation":[{"name":"Institut de Pharmacologie et de Biologie Structurale  205\u2005Route de Narbonne 31077 Toulouse Cedex\u20054 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gis\u00e8le","family":"Gellon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes D\u00e9partement de Chimie Mol\u00e9culaire UMR-5250  38041 Grenoble Cedex\u20059 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Dejeu","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes D\u00e9partement de Chimie Mol\u00e9culaire UMR-5250  38041 Grenoble Cedex\u20059 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Lavergne","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes D\u00e9partement de Chimie Mol\u00e9culaire UMR-5250  38041 Grenoble Cedex\u20059 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Jamet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes D\u00e9partement de Chimie Mol\u00e9culaire UMR-5250  38041 Grenoble Cedex\u20059 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Gomez","sequence":"additional","affiliation":[{"name":"Institut de Pharmacologie et de Biologie Structurale  205\u2005Route de Narbonne 31077 Toulouse Cedex\u20054 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Louis","family":"Mergny","sequence":"additional","affiliation":[{"name":"ARNA laboratory Inserm U1212, CNRS UMR 5320 Institut Europ\u00e9en de Chimie et Biologie IECB \u2013 Universit\u00e9 de Bordeaux  2\u2005rue Robert Escarpit 33607 Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Defrancq","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes D\u00e9partement de Chimie Mol\u00e9culaire UMR-5250  38041 Grenoble Cedex\u20059 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Jarjayes","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes D\u00e9partement de Chimie Mol\u00e9culaire UMR-5250  38041 Grenoble Cedex\u20059 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Thomas","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes D\u00e9partement de Chimie Mol\u00e9culaire UMR-5250  38041 Grenoble Cedex\u20059 France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,11]]},"reference":[{"key":"e_1_2_2_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2009.05.002"},{"key":"e_1_2_2_2_1","unstructured":"\u00a0"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201002387"},{"key":"e_1_2_2_3_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201002387"},{"key":"e_1_2_2_4_2","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1684\/bdc.2011.1378","volume":"98","author":"Rajpar S.","year":"2011","journal-title":"Bull. 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