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They are a burden to human and animal health, having the most devastating effect on the world\u2032s poorest countries. Building upon our previously reported triazole analogues, in this study we describe the synthesis and biological testing of other novel heterocyclic acetogenin\u2010inspired derivatives, namely 3,5\u2010isoxazoles, furoxans, and furazans. Several of these compounds maintain low\u2010micromolar levels of inhibition against <jats:italic>Trypanosoma brucei<\/jats:italic>, whilst having no observable inhibitory effect on mammalian cells, leading to the possibility of novel lead compounds for selective treatment.<\/jats:p>","DOI":"10.1002\/cmdc.201600210","type":"journal-article","created":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T06:08:03Z","timestamp":1465538883000},"page":"1503-1506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Development of Simplified Heterocyclic Acetogenin Analogues as Potent and Selective <i>Trypanosoma brucei<\/i> Inhibitors"],"prefix":"10.1002","volume":"11","author":[{"given":"Gordon J.","family":"Florence","sequence":"first","affiliation":[{"name":"EaStCHEM School of Chemistry and School of Biology Biomedical Sciences Research Complex University of St.\u2005Andrews  North Haugh St.\u2005Andrews KY16\u20059ST 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