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The most active compounds were found to be bisphosphonates with electron\u2010withdrawing aryl\u2010alkyl side chains which inhibited the growth of Gram\u2010negative bacteria (<jats:italic>Acinetobacter baumannii<\/jats:italic>, <jats:italic>Klebsiella pneumoniae<\/jats:italic>, <jats:italic>Escherichia coli<\/jats:italic>, and <jats:italic>Pseudomonas aeruginosa<\/jats:italic>) at \u223c1\u20134\u2005\u03bcg\u2009mL<jats:sup>\u22121<\/jats:sup> levels. They were found to be potent inhibitors of FPPS; cell growth was partially \u201crescued\u201d by the addition of farnesol or overexpression of FPPS, and there was synergistic activity with known isoprenoid biosynthesis pathway inhibitors. Lipophilic hydroxyalkyl phosphonic acids inhibited UPPS and UPPP at micromolar levels; they were active (\u223c2\u20136\u2005\u03bcg\u2009mL<jats:sup>\u22121<\/jats:sup>) against Gram\u2010positive but not Gram\u2010negative organisms, and again exhibited synergistic activity with cell wall biosynthesis inhibitors, but only indifferent effects with other inhibitors. The results are of interest because they describe novel inhibitors of FPPS, UPPS, and UPPP with cell growth inhibitory activities as low as \u223c1\u20132\u2005\u03bcg\u2009mL<jats:sup>\u22121<\/jats:sup>.<\/jats:p>","DOI":"10.1002\/cmdc.201600343","type":"journal-article","created":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T07:54:04Z","timestamp":1472543644000},"page":"2205-2215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Isoprenoid Biosynthesis Inhibitors Targeting Bacterial Cell Growth"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5487-1264","authenticated-orcid":false,"given":"Janish","family":"Desai","sequence":"first","affiliation":[{"name":"Center for Biophysics and Quantitative Biology University of Illinois at Urbana\u2013Champaign  1110 West Green Street Urbana IL 61801 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Illinois at Urbana\u2013Champaign  600 South Mathews Avenue Urbana IL 61801 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Illinois at Urbana\u2013Champaign  600 South Mathews Avenue Urbana IL 61801 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish R.","family":"Malwal","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Illinois at Urbana\u2013Champaign  600 South Mathews Avenue Urbana IL 61801 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Oldfield","sequence":"additional","affiliation":[{"name":"Center for Biophysics and Quantitative Biology University of Illinois at Urbana\u2013Champaign  1110 West Green Street Urbana IL 61801 USA"},{"name":"Department of Chemistry University of Illinois at Urbana\u2013Champaign  600 South Mathews Avenue Urbana IL 61801 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,30]]},"reference":[{"key":"e_1_2_6_1_1","unstructured":"Antibiotic Resistance Threats in the United States 2013 US Department of Health and Human Services Centers for Disease Control and Prevention (CDC):http:\/\/www.cdc.gov\/drugresistance\/pdf\/ar-threats-2013-508.pdf."},{"key":"e_1_2_6_2_1","unstructured":"\u00a0"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.tips.2014.10.007","volume":"35","author":"Oldfield E.","year":"2014","journal-title":"Trends Pharmacol. 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