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Compounds <jats:bold>6\u2009a<\/jats:bold>\u2013<jats:bold>g<\/jats:bold> (amide derivatives) and <jats:bold>7\u2009a<\/jats:bold>\u2013<jats:bold>h<\/jats:bold> (triazoles) act as \u201cprodrugs\u201d, and their hydrolysis products are the de\u2005facto CA inhibitors. These compounds displayed sub\u2010micromolar to high\u2010nanomolar inhibitory activity against hCA isoforms IX and XII, which were recently validated as antitumor drug targets. Moreover, no inhibition of the off\u2010target hCA\u2005I and II isoforms was observed. Compounds <jats:bold>8\u2009a<\/jats:bold>\u2013<jats:bold>f<\/jats:bold> (another set of triazoles) exhibited nanomolar inhibition against hCA isoforms\u2005I, II, IX and XII, among which compounds <jats:bold>8\u2009c<\/jats:bold>, <jats:bold>8\u2009d<\/jats:bold>, and <jats:bold>8\u2009f<\/jats:bold> were found to inhibit the tumor\u2010associated hypoxia\u2010induced hCA isoform\u2005IX with <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values of 1.8, 2.3, and 2.0\u2005n<jats:sc>m<\/jats:sc> respectively. Further exploration of these compounds could be useful for the development of novel antitumor agents with selective mechanisms of CA inhibitory action.<\/jats:p>","DOI":"10.1002\/cmdc.201700446","type":"journal-article","created":{"date-parts":[[2017,9,2]],"date-time":"2017-09-02T08:22:39Z","timestamp":1504340559000},"page":"1578-1584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Sulfocoumarin\u2010, Coumarin\u2010, 4\u2010Sulfamoylphenyl\u2010Bearing Indazole\u20103\u2010carboxamide Hybrids: Synthesis and Selective Inhibition of Tumor\u2010Associated Carbonic Anhydrase Isozymes IX and XII"],"prefix":"10.1002","volume":"12","author":[{"given":"Srinivas","family":"Angapelly","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry National Institute of Pharmaceutical Education &amp; Research (NIPER)  Hyderabad 500037 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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