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Novel \u03b1\u2010branched acyclic nucleoside phosphonates (ANPs) having a hemiaminal ether moiety were synthesized as potential inhibitors of bacterial adenylate cyclases. ANPs prepared as bisamidates were not cytotoxic, but did not exhibit any profound activity (IC<jats:sub>50<\/jats:sub>&gt;10\u2005\u03bc<jats:sc>m<\/jats:sc>) toward ACT in J774A.1 macrophages. The apparent lack of activity of the bisamidates is speculated to be due to the inefficient formation of the biologically active species (ANPpp) in the cells. Conversely, two 5\u2010haloanthraniloyl\u2010substituted ANPs in the form of diphosphates were shown to be potent ACT and EF inhibitors with IC<jats:sub>50<\/jats:sub> values ranging from 55 to 362\u2005n<jats:sc>m<\/jats:sc>.<\/jats:p>","DOI":"10.1002\/cmdc.201700715","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T04:36:49Z","timestamp":1513139809000},"page":"199-206","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Synthesis of \u03b1\u2010Branched Acyclic Nucleoside Phosphonates as Potential Inhibitors of Bacterial Adenylate Cyclases"],"prefix":"10.1002","volume":"13","author":[{"given":"Jan","family":"Frydrych","sequence":"first","affiliation":[{"name":"Institute of Organic Chemistry and Biochemistry Czech Academy of Sciences  Flemingovo n\u00e1m. 2 166\u200910 Prague 6 Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Sk\u00e1cel","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry and Biochemistry Czech Academy of Sciences  Flemingovo n\u00e1m. 2 166\u200910 Prague 6 Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark\u00e9ta","family":"\u0160m\u00eddkov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry and Biochemistry Czech Academy of Sciences  Flemingovo n\u00e1m. 2 166\u200910 Prague 6 Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Mertl\u00edkov\u00e1\u2010Kaiserov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry and Biochemistry Czech Academy of Sciences  Flemingovo n\u00e1m. 2 166\u200910 Prague 6 Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Dra\u010d\u00ednsk\u00fd","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry and Biochemistry Czech Academy of Sciences  Flemingovo n\u00e1m. 2 166\u200910 Prague 6 Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramachandran","family":"Gnanasekaran","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry and Biochemistry Czech Academy of Sciences  Flemingovo n\u00e1m. 2 166\u200910 Prague 6 Czech Republic"},{"name":"Current address: Department of Chemistry Pondicherry University  Puducherry 605014 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Lep\u0161\u00edk","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry and Biochemistry Czech Academy of Sciences  Flemingovo n\u00e1m. 2 166\u200910 Prague 6 Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Soto\u2010Velasquez","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Molecular Pharmacology College of Pharmacy Purdue University  575 Stadium Mall Drive West Lafayette IN 47907 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val J.","family":"Watts","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Molecular Pharmacology College of Pharmacy Purdue University  575 Stadium Mall Drive West Lafayette IN 47907 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4654-679X","authenticated-orcid":false,"given":"Zlatko","family":"Janeba","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry and Biochemistry Czech Academy of Sciences  Flemingovo n\u00e1m. 2 166\u200910 Prague 6 Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,8]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"World Health Organization Geneva Switzerland http:\/\/www.who.int\/immunization\/monitoring_surveillance\/burden\/estimates\/en\/accessed August 17 2017."},{"key":"e_1_2_7_2_1","unstructured":"\u00a0"},{"key":"e_1_2_7_3_2","first-page":"628","volume":"22","author":"Vitek C. 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