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To obtain low\u2010molecular\u2010weight copper chelators that act as tetradentate ligands, we designed new compounds based on an 8\u2010aminoquinoline motif with a lateral chain attached at the 2\u2010position of the aromatic ring. Some of these new ligands, termed TDMQ for TetraDentate MonoQuinolines, are specific for copper chelation. Full characterization of these ligands is reported, as well as their affinities for Cu<jats:sup>II<\/jats:sup>, and their capacities to inhibit oxidative stress induced by copper\u2013amyloids activated by a reductant. Such metal ligands can be considered as potential anti\u2010AD agents, as they should be able to regulate the homeostasis of copper in brain tissue.<\/jats:p>","DOI":"10.1002\/cmdc.201700734","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T13:56:35Z","timestamp":1518098195000},"page":"684-704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Preparation of Tetradentate Copper Chelators as Potential Anti\u2010Alzheimer Agents"],"prefix":"10.1002","volume":"13","author":[{"given":"Weixin","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Chemical Engineering and Light Industry Guangdong University of Technology (GDUT)  no. 100 Waihuan Xi Road, Education Mega Center Guangzhou P.R. 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