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The overall eight\u2010year survival rate for CML has increased from about 6\u2009% in the 1970s to over 90\u2009% in the imatinib era. However, about 20\u2009% of CML patients harbor primary or acquired resistance to tyrosine kinase inhibitors. ABL1 point mutations in the BCR\u2010ABL1 fusion protein, such as ABL1(T315I), typically emerge after prolonged kinase inhibitor treatment. Ponatinib (AP24534) is currently the only approved CML drug that is active against the ABL1(T315I) mutation. However, ponatinib has severe cardiovascular toxicities; hence, there have been efforts to find safer CML drugs that work against ABL1 secondary mutations. We reveal that isoquinoline\u2010 or naphthyridine\u2010based compounds, such as HSN431, HSN576, HSN459, and HSN608 potently inhibit the enzymatic activities of ABL1, ABL1(T315I), and ABL1(E255K). These compounds inhibit the proliferation of ABL1\u2010driven CML cell lines, K652 and KCL22 as well as the drug\u2010resistant cell line, KCL22\u2010IR, which harbors the secondary mutated ABL1(T315I) kinase.<\/jats:p>","DOI":"10.1002\/cmdc.201700829","type":"journal-article","created":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T14:52:31Z","timestamp":1522680751000},"page":"1172-1180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Alkynylnicotinamide\u2010Based Compounds as ABL1 Inhibitors with Potent Activities against Drug\u2010Resistant CML Harboring ABL1(T315I) Mutant Kinase"],"prefix":"10.1002","volume":"13","author":[{"given":"Elizabeth A.","family":"Larocque","sequence":"first","affiliation":[{"name":"Department of Chemistry Purdue University  West Lafayette IN 47907 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Naganna","sequence":"additional","affiliation":[{"name":"Department of Chemistry Purdue University  West Lafayette IN 47907 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8140-4637","authenticated-orcid":false,"given":"Clement","family":"Opoku\u2010Temeng","sequence":"additional","affiliation":[{"name":"Department of Chemistry Purdue University  West Lafayette IN 47907 USA"},{"name":"Graduate Program in Biochemistry University of Maryland  College Park MD 20742 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyssa M.","family":"Lambrecht","sequence":"additional","affiliation":[{"name":"Department of Chemistry Purdue University  West Lafayette IN 47907 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2280-9359","authenticated-orcid":false,"given":"Herman O.","family":"Sintim","sequence":"additional","affiliation":[{"name":"Department of Chemistry Purdue University  West Lafayette IN 47907 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,22]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-05-0101"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-015-0143-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0b013e318237e5b7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1009-1153"},{"key":"e_1_2_7_5_1","first-page":"243","volume":"8","author":"Miller G.","year":"2014","journal-title":"Biologics"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062867"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912614"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1002315"},{"key":"e_1_2_7_9_1","first-page":"2075","volume":"367","author":"Brummendorf T. 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