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Many indazoles of series <jats:bold>A<\/jats:bold>, <jats:bold>B<\/jats:bold>, and <jats:bold>C<\/jats:bold> were efficient against <jats:italic>T.\u2005cruzi<\/jats:italic>. Some compounds in series <jats:bold>A<\/jats:bold>, after successfully passing the preliminary screening for epimastigotes, exhibited activity values against amastigotes of several <jats:italic>T.\u2005cruzi<\/jats:italic> strains that were better than or similar to those shown by the reference drug benznidazole and displayed low nonspecific toxicity against mammalian cells. On the other hand, preliminary studies against promastigotes of <jats:italic>L.\u2005amazonensis<\/jats:italic> showed high leishmanicidal activity for some derivatives of series <jats:bold>A<\/jats:bold> and <jats:bold>C<\/jats:bold>. With regard to activity against <jats:italic>T.\u2005vaginalis<\/jats:italic>, some indazoles of series <jats:bold>B<\/jats:bold> and <jats:bold>C<\/jats:bold> were rather efficient against trophozoites of a metronidazole\u2010sensitive isolate and showed low nonspecific toxicities toward Vero cell cultures. Additionally, some of these compounds displayed similar activity against metronidazole\u2010sensitive and resistant isolates, showing the absence of cross\u2010resistance between these derivatives and the reference drug.<\/jats:p>","DOI":"10.1002\/cmdc.201800084","type":"journal-article","created":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T17:36:22Z","timestamp":1523036182000},"page":"1246-1259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Antichagasic, Leishmanicidal, and Trichomonacidal Activity of 2\u2010Benzyl\u20105\u2010nitroindazole\u2010Derived Amines"],"prefix":"10.1002","volume":"13","author":[{"given":"Cristina","family":"Fonseca\u2010Berzal","sequence":"first","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Parasitolog\u00eda, Facultad de Farmacia Universidad Complutense de Madrid (UCM)  Plaza de Ram\u00f3n y Cajal s\/n 28040 Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8687-1100","authenticated-orcid":false,"given":"Alexandra","family":"Ib\u00e1\u00f1ez\u2010Escribano","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Parasitolog\u00eda, Facultad de Farmacia Universidad Complutense de Madrid (UCM)  Plaza de Ram\u00f3n y Cajal s\/n 28040 Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerea","family":"Vela","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica M\u00e9dica (IQM) Consejo Superior de Investigaciones Cient\u00edficas (CSIC)  c\/ Juan de la Cierva 3 28006 Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Cumella","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica M\u00e9dica (IQM) Consejo Superior de Investigaciones Cient\u00edficas (CSIC)  c\/ Juan de la Cierva 3 28006 Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8714-049X","authenticated-orcid":false,"given":"Juan Jos\u00e9","family":"Nogal\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Parasitolog\u00eda, Facultad de Farmacia Universidad Complutense de Madrid (UCM)  Plaza de Ram\u00f3n y Cajal s\/n 28040 Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4742-2783","authenticated-orcid":false,"given":"Jos\u00e9 Antonio","family":"Escario","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Parasitolog\u00eda, Facultad de Farmacia Universidad Complutense de Madrid (UCM)  Plaza de Ram\u00f3n y Cajal s\/n 28040 Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Bernardino","family":"da\u2005Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biologia Celular Instituto Oswaldo Cruz, Fiocruz  Av. 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