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A group of gold\u2010 or silver\u2010based complexes, of general formula [M(PEt<jats:sub>3<\/jats:sub>)X] (with M=Au or Ag, and X=Cl, Br or I), alongside with three complexes bearing a positive or negative charge\u2014[Au(PEt<jats:sub>3<\/jats:sub>)<jats:sub>2<\/jats:sub>]Cl, K[Au(CN)<jats:sub>2<\/jats:sub>] and [Ag(PEt<jats:sub>3<\/jats:sub>)<jats:sub>2<\/jats:sub>]NO<jats:sub>3<\/jats:sub>\u2014were prepared and comparatively tested with auranofin on a representative panel of pathogens including Gram\u2010positive, Gram\u2010negative and <jats:italic>Candida<\/jats:italic> strains. Interestingly, all the gold and silver complexes tested were active on Gram\u2010positive strains, with the gold complexes having greater efficacy. The effects of the gold compounds were potentiated to a larger extent than silver compounds when tested in combination with a permeabilizing agent. A number of relevant structure\u2013activity relationships emerged from the comparative analysis of the observed antibacterial profiles, shedding new light on the underlying molecular mechanisms of the action of these compounds.<\/jats:p>","DOI":"10.1002\/cmdc.201800498","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T11:54:17Z","timestamp":1537876457000},"page":"2448-2454","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Auranofin and its Analogues Show Potent Antimicrobial Activity against Multidrug\u2010Resistant Pathogens: Structure\u2013Activity Relationships"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2567-3637","authenticated-orcid":false,"given":"Tiziano","family":"Marzo","sequence":"first","affiliation":[{"name":"Laboratory of Metals in Medicine (MetMed), Department of Chemistry \u201cU. 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