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Unfortunately, available therapies are unsatisfactory, due primarily to safety issues and development of drug resistance. Over the last decades significant effort has been made in the discovery of new potential anti\u2010HAT agents, with help from the World Health Organization (WHO) and private\u2013public partnerships such as the Drugs for Neglected Diseases Initiative (DNDi). Whereas antifolates have been a valuable source of drugs against bacterial infections and malaria, compounds effective against\n                    <jats:italic>T.\u2005brucei<\/jats:italic>\n                    have not yet been identified. Considering the relatively simple folate metabolic pathway in\n                    <jats:italic>T.\u2005brucei<\/jats:italic>\n                    , along with results obtained in this research field so far, we believe that further investigations might lead to effective chemotherapeutic agents. Herein we present a selection of the more promising results obtained so far in this field, underlining the opportunities that could lead to successful therapeutic approaches in the future.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.201800500","type":"journal-article","created":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T16:41:45Z","timestamp":1535560905000},"page":"2150-2158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Folates in\n                    <i>Trypanosoma brucei<\/i>\n                    : Achievements and Opportunities"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2097-8263","authenticated-orcid":false,"given":"Gregorio","family":"Cullia","sequence":"first","affiliation":[{"name":"Institute of Biomolecules Max Mousseron (IBMM) UMR5247 CNRS University of Montpellier ENSCM  Place Eug\u00e8ne Battaillon 34095 Montpellier cedex 5 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9755-7846","authenticated-orcid":false,"given":"Lucia","family":"Tamborini","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences (DISFARM) University of Milan  via Luigi Mangiagalli 25 20133 Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2140-0567","authenticated-orcid":false,"given":"Paola","family":"Conti","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences (DISFARM) University of Milan  via Luigi Mangiagalli 25 20133 Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3549-4365","authenticated-orcid":false,"given":"Carlo","family":"De\u2005Micheli","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences (DISFARM) University of Milan  via Luigi Mangiagalli 25 20133 Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2501-3348","authenticated-orcid":false,"given":"Andrea","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Food Environmental and Nutritional Sciences University of Milan  via Giovanni Celoria 2 20133 Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,24]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"\u00a0"},{"key":"e_1_2_8_2_2","unstructured":"World Health Organization Trypanosomiasis human African (sleeping sickness) http:\/\/www.who.int\/news-room\/fact-sheets\/detail\/trypanosomiasis-human-african-(sleeping-sickness) (accessed May 2018);"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31510-6"},{"key":"e_1_2_8_4_1","unstructured":"\u00a0"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60829-1"},{"key":"e_1_2_8_6_2","first-page":"257","volume":"6","author":"Franco J. 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