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Developing new antibiotic agents is vital for fighting persistent infections and lowering mortality rates. In this study, we designed lutidine\u2010disubstituted bis\u2010benzimidazolium salts (lutidine\u2010bis\u2010benzimidazolium core with octyl, adamantyl, and cholesteryl lipophilic side chains), and tested their antimicrobial activity, their capacity to inhibit planktonic bacterial and fungal growth, and their ability to inhibit the formation of or disrupt mature methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA) biofilms. The antibiofilm activity of these salts was analyzed in terms of their lipophilicity, capacity to induce transmembrane ion transport, perturbation of the cellular membrane, and mechanism of action in the phospholipid bilayer. The synthesized compounds were not active against MRSA biofilms, as the formation of transmembrane channels had no effect on the integrity of the extracellular polymeric substance matrix and only octyl and adamantyl derivatives possessed the capacity to inhibit biofilm formation. The synthesized derivatives could be used as lead candidates for the development of anti\u2010MRSA agents.<\/jats:p>","DOI":"10.1002\/cmdc.201800639","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T22:14:35Z","timestamp":1540419275000},"page":"2567-2572","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Antimicrobial and Antibiofilm Activity of Disubstituted Bis\u2010benzimidazolium Salts"],"prefix":"10.1002","volume":"13","author":[{"given":"J\u00e9r\u00e9mie","family":"Tessier","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Montr\u00e9al, Facult\u00e9 des Arts et des Sciences  2900 Edouard Montpetit, CP\u20056128 succursalle centre ville Montr\u00e9al QC H3C\u20053J7 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaux","family":"Lecluse","sequence":"additional","affiliation":[{"name":"Department of Chemistry 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