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Their widespread use helped reveal their other modes of action as pharmaceuticals, such as a profound effect on various cancers. Celecoxib has proven to be a very prominent member of this group with cytostatic activities. On the other hand, the highly dynamic field of drug design is constantly searching for new ways of modifying known structures to obtain more powerful and less harmful drugs. A very interesting development is the implementation of carboranes in pharmacologically active structures, mostly as phenyl mimetics. Herein we report the synthesis of three carborane\u2010containing derivatives of the COX\u20102\u2010selective NSAID celecoxib. The new compounds proved to have promising cytostatic potential against various melanoma and colorectal adenocarcinoma cell lines. Inhibited proliferation accompanied by caspase\u2010independent apoptotic cell death was found to be the main cause of decreased cell viability upon treatment with the most efficient celecoxib analogue, <jats:bold>3\u2009b<\/jats:bold> (4\u2010[5\u2010(1,7\u2010dicarba\u2010<jats:italic>closo<\/jats:italic>\u2010dodecaboranyl)\u20103\u2010trifluoromethyl\u20101<jats:italic>H<\/jats:italic>\u2010pyrazol\u20101\u2010yl]\u20101\u2010methylsulfonylbenzene).<\/jats:p>","DOI":"10.1002\/cmdc.201800685","type":"journal-article","created":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T13:41:26Z","timestamp":1546436486000},"page":"315-321","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Carboranyl Analogues of Celecoxib with Potent Cytostatic Activity against Human Melanoma and Colon Cancer Cell Lines"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1271-3553","authenticated-orcid":false,"given":"Antonio","family":"Buzharevski","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Anorganische Chemie Universit\u00e4t Leipzig  Johannisallee 29 04103 Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1206-5376","authenticated-orcid":false,"given":"Svetlana","family":"Paskas","sequence":"additional","affiliation":[{"name":"Department of Immunology Institute for Biological Research \u201cSinisa Stankovic\u201d Belgrade University  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4222-0717","authenticated-orcid":false,"given":"Menyh\u00e1rt\u2010Botond","family":"S\u00e1rosi","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Anorganische Chemie Universit\u00e4t Leipzig  Johannisallee 29 04103 Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4916-3794","authenticated-orcid":false,"given":"Markus","family":"Laube","sequence":"additional","affiliation":[{"name":"Institute of Radiopharmaceutical Cancer Research Department of Radiopharmaceutical and Chemical Biology Helmholtz-Zentrum Dresden-Rossendorf  Bautzner Landstrasse 400 01328 Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1335-0897","authenticated-orcid":false,"given":"Peter","family":"L\u00f6nnecke","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Anorganische Chemie Universit\u00e4t Leipzig  Johannisallee 29 04103 Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1728-5140","authenticated-orcid":false,"given":"Wilma","family":"Neumann","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Anorganische Chemie Universit\u00e4t Leipzig  Johannisallee 29 04103 Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9509-9098","authenticated-orcid":false,"given":"Sanja","family":"Mijatovic","sequence":"additional","affiliation":[{"name":"Department of Immunology Institute for Biological Research \u201cSinisa Stankovic\u201d Belgrade University  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8006-5079","authenticated-orcid":false,"given":"Danijela","family":"Maksimovic\u2010Ivanic","sequence":"additional","affiliation":[{"name":"Department of Immunology Institute for Biological Research \u201cSinisa Stankovic\u201d Belgrade University  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1610-1493","authenticated-orcid":false,"given":"Jens","family":"Pietzsch","sequence":"additional","affiliation":[{"name":"Institute of Radiopharmaceutical Cancer Research Department of Radiopharmaceutical and Chemical Biology Helmholtz-Zentrum Dresden-Rossendorf  Bautzner Landstrasse 400 01328 Dresden Germany"},{"name":"Faculty of Chemistry and Food Chemistry Technische Universit\u00e4t Dresden  Mommsenstrasse 4 01062 Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4267-0603","authenticated-orcid":false,"given":"Evamarie","family":"Hey\u2010Hawkins","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Anorganische Chemie Universit\u00e4t Leipzig  Johannisallee 29 04103 Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,23]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/1-4020-5688-5_1","volume-title":"Inflammation in the Pathogenesis of Chronic Diseases, Vol.\u200542","author":"Rainsford K. 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