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The cytotoxic effect of all compounds was examined on human cervical cancer (HeLa) cells, revealing strong anticancer activity. After 24\u2005h, only complexes with the (HOCH<jats:sub>2<\/jats:sub>CH<jats:sub>2<\/jats:sub>CH<jats:sub>2<\/jats:sub>)<jats:sub>2<\/jats:sub>(<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/cmdc201800702-math-0002.png\" xlink:title=\"urn:x-wiley:18607179:media:cmdc201800702:cmdc201800702-math-0002\"\/>\nPhCH<jats:sub>2<\/jats:sub>)<jats:sub>2<\/jats:sub>Cyclam ligand are cytotoxic, whereas after incubation for 72\u2005h all compounds show significant antiproliferative effects. Notably, compounds containing <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/cmdc201800702-math-0003.png\" xlink:title=\"urn:x-wiley:18607179:media:cmdc201800702:cmdc201800702-math-0003\"\/>\nPhCH<jats:sub>2<\/jats:sub> pendant arms on the cyclam ring revealed the most activity, with cytotoxicity values up to 12 times higher than those of cisplatin. All metal complexes seem to induce cell death through the formation of reactive oxygen species.<\/jats:p>","DOI":"10.1002\/cmdc.201800702","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T16:25:36Z","timestamp":1548779136000},"page":"770-778","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["New Cyclams and Their Copper(II) and Iron(III) Complexes: Synthesis and Potential Application as Anticancer Agents"],"prefix":"10.1002","volume":"14","author":[{"given":"Adhan","family":"Pilon","sequence":"first","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural Faculdade de Ci\u00eancias da Universidade de Lisboa  Campo Grande 1749-016 Lisbon Portugal"},{"name":"Centro de Qu\u00edmica Estrutural Instituto Superior T\u00e9cnico Universidade de Lisboa  Av. 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