{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:04:46Z","timestamp":1787241886386,"version":"build-2736575974"},"reference-count":68,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T00:00:00Z","timestamp":1545264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research","doi-asserted-by":"publisher","award":["01(2913)\/17\/EMR-II"],"award-info":[{"award-number":["01(2913)\/17\/EMR-II"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2019,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Simultaneous C\u2212N, and N\u2212N bond\u2010forming methods for one\u2010pot transformations are highly challenging in synthetic organic chemistry. In this study, the Cu\n                    <jats:sub>2<\/jats:sub>\n                    O rhombic dodecahedra\u2010catalyzed synthesis of 2\n                    <jats:italic>H<\/jats:italic>\n                    \u2010indazoles is demonstrated with good to excellent yields from readily available chemicals. This one\u2010pot procedure involves Cu\n                    <jats:sub>2<\/jats:sub>\n                    O nanoparticle\u2010catalyzed consecutive C\u2212N, and N\u2212N bond formation followed by cyclization to yield 2\n                    <jats:italic>H<\/jats:italic>\n                    \u2010indazoles with broad substrate scope and high functional group tolerance. Various cell\u2010based bioassay studies demonstrated that 2\n                    <jats:italic>H<\/jats:italic>\n                    \u2010indazoles inhibit the growth of cancer cells, typically through induction of apoptosis in a dose\u2010dependent manner. Moreover, 2\n                    <jats:italic>H<\/jats:italic>\n                    \u2010indazoles tested in the MDA\u2010MB\u2010468 cell line were capable of inhibiting cancer cell migration and invasion. Thus, it is shown that 2\n                    <jats:italic>H<\/jats:italic>\n                    \u2010indazoles have potent in vitro anticancer activity that warrant further investigation of this compound class.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.201800707","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T09:54:16Z","timestamp":1542102856000},"page":"262-272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Assembly of Fully Substituted 2\n                    <i>H<\/i>\n                    \u2010Indazoles Catalyzed by Cu\n                    <sub>2<\/sub>\n                    O Rhombic Dodecahedra and Evaluation of Anticancer Activity"],"prefix":"10.1002","volume":"14","author":[{"given":"Rajeeva Lochana","family":"Panchangam","sequence":"first","affiliation":[{"name":"Department of Biosciences, School of Bioscience and Technology Vellore Institute of 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