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These new hybrids were screened in\u2005vitro against asexual blood stages of the chloroquine\u2010sensitive 3D7 strain of <jats:italic>P.\u2005falciparum<\/jats:italic>. The most active compounds were further screened against asexual and sexual stages (gametocytes) of the chloroquine\u2010resistant RKL\u20109 strain of <jats:italic>P.\u2005falciparum<\/jats:italic>. Although all compounds were less potent than chloroquine against the 3D7 strain, the three best compounds were appreciably more active than chloroquine against the RKL\u20109 strain, displaying IC<jats:sub>50<\/jats:sub> values of &lt;100\u2005n<jats:sc>m<\/jats:sc>, with one of them having an IC<jats:sub>50<\/jats:sub> of 2.94\u2005n<jats:sc>m<\/jats:sc>. Further, the lead compounds were gametocytocidal with IC<jats:sub>50<\/jats:sub> values in the micromolar range, and were observed to induce morphological deformations in mature gametocytes. Most compounds demonstrated little or no cytotoxicity and exhibited good selectivity indices. The most active compounds represent promising candidates for further evaluation of their schizonticidal and gametocytocidal potential.<\/jats:p>","DOI":"10.1002\/cmdc.201800728","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T14:27:29Z","timestamp":1546612049000},"page":"484-493","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Targeting Asexual and Sexual Blood Stages of the Human Malaria Parasite <i>P.\u2005falciparum<\/i> with 7\u2010Chloroquinoline\u2010Based 1,2,3\u2010Triazoles"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0443-8491","authenticated-orcid":false,"given":"Ishan","family":"Wadi","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Delhi  Delhi 110007 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davinder","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Delhi  Delhi 110007 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Batra","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Delhi  Delhi 110007 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumkum","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Parasitology Division Central Drug Research Institute, Lucknow  226031 Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupkumar R.","family":"Anvikar","sequence":"additional","affiliation":[{"name":"ICMR\u2014National Institute of Malaria Research, Dwarka  New Delhi 110077 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neena","family":"Valecha","sequence":"additional","affiliation":[{"name":"ICMR\u2014National Institute of Malaria Research, Dwarka  New Delhi 110077 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3088-1422","authenticated-orcid":false,"given":"Mahendra","family":"Nath","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Delhi  Delhi 110007 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,29]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"World Malaria Report 2016 World Health Organization Geneva 2016 License: CC-BY-NC-SA 3.0 IGO;https:\/\/www.who.int\/malaria\/publications\/world-malaria-report-2016\/report\/en\/(last accessed January 21 2019)."},{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S1473-3099(17)30048-8","volume":"17","author":"Imwong M.","year":"2017","journal-title":"Lancet Infect. 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