{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:23:15Z","timestamp":1787761395982,"version":"build-2784847793"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T00:00:00Z","timestamp":1556582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2019,5,17]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The rise of antibiotic resistance, especially in <jats:italic>Staphylococcus aureus<\/jats:italic>, and the increasing death rate due to multiresistant bacteria have been well documented. The need for new chemical entities and\/or the identification of novel targets for antibacterial drug development is high. Lipoteichoic acid (LTA), a membrane\u2010attached anionic polymer, is important for the growth and virulence of many Gram\u2010positive bacteria, and interest has been high in the discovery of LTA biosynthesis inhibitors. Thus far, only a handful of LTA biosynthesis inhibitors have been described with moderate (MIC=5.34\u2005\u03bcg\u2009mL<jats:sup>\u22121<\/jats:sup>) to low (MIC=1024\u2005\u03bcg\u2009mL<jats:sup>\u22121<\/jats:sup>) activities against <jats:italic>S.\u2005aureus<\/jats:italic>. Herein we describe the identification of novel compounds that potently inhibit LTA biosynthesis in <jats:italic>S.\u2005aureus<\/jats:italic>, displaying impressive antibacterial activities (MIC as low as 0.25\u2005\u03bcg\u2009mL<jats:sup>\u22121<\/jats:sup>) against methicillin\u2010resistant <jats:italic>S.\u2005aureus<\/jats:italic> (MRSA). Under similar in\u2005vitro assay conditions, these compounds are 4\u2010fold more potent than vancomycin and 8\u2010fold more potent than linezolid against MRSA.<\/jats:p>","DOI":"10.1002\/cmdc.201900053","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T14:38:52Z","timestamp":1554215932000},"page":"1000-1004","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Antibacterial Small Molecules That Potently Inhibit <i>Staphylococcus aureus<\/i> Lipoteichoic Acid Biosynthesis"],"prefix":"10.1002","volume":"14","author":[{"given":"George A.","family":"Naclerio","sequence":"first","affiliation":[{"name":"Chemistry Department, Institute for Drug Discovery Purdue University  West Lafayette IN 47907 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline W.","family":"Karanja","sequence":"additional","affiliation":[{"name":"Chemistry Department, Institute for Drug 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