{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:56:24Z","timestamp":1760550984597,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012352","name":"Universit\u00e0 degli Studi di Milano","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012352","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2019,12,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The treatment of malaria, the most common parasitic disease worldwide and the third deadliest infection after HIV and tuberculosis, is currently compromised by the dramatic increase and diffusion of drug resistance among the various species of <jats:italic>Plasmodium<\/jats:italic>, especially <jats:italic>P. falciparum<\/jats:italic> (<jats:italic>Pf<\/jats:italic>). In this view, the development of new antiplasmodial agents that are able to act <jats:italic>via<\/jats:italic> innovative mechanisms of action, is crucial to ensure efficacious antimalarial treatments. In one of our previous communications, we described a novel class of compounds endowed with high antiplasmodial activity, characterized by a pharmacophore never described before as antiplasmodial and identified by their 4,4\u2019\u2010oxybisbenzoyl amide cores. Here, through a detailed structure\u2010activity relationship (SAR) study, we thoroughly investigated the chemical features of the reported scaffolds and successfully built a novel antiplasmodial agent active on both chloroquine (CQ)\u2010sensitive and CQ\u2010resistant <jats:italic>Pf<\/jats:italic> strains in the low nanomolar range, without displaying cross\u2010resistance. Moreover, we conducted an <jats:italic>in silico<\/jats:italic> pharmacophore mapping.<\/jats:p>","DOI":"10.1002\/cmdc.201900526","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T13:48:28Z","timestamp":1572443308000},"page":"1982-1994","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Discovery and Pharmacophore Mapping of a Low\u2010Nanomolar Inhibitor of <i>P. falciparum<\/i> Growth"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9589-3689","authenticated-orcid":false,"given":"Ivan","family":"Bassanini","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Farmaceutiche Universit\u00e0 degli Studi di Milano  Via Mangiagalli 25 20133 Milan Italy"},{"name":"Centro Interuniversitario di Ricerca sulla Malaria-Italian Malaria 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