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Thus, in view of the lack of efficient therapies and increasing resistances against existing drugs, this study describes the antiprotozoal potential of synthetic cinnamate ester analogues and their structure\u2010activity relationships. In general, <jats:italic>Leishmania donovani<\/jats:italic> and <jats:italic>Trypanosoma brucei<\/jats:italic> were quite susceptible to the compounds in a structure\u2010dependent manner. Detailed analysis revealed a key role of the substitution pattern on the aromatic ring and a marked effect of the side chain on the activity against these two parasites. The high antileishmanial potency and remarkable selectivity of the nitro\u2010aromatic derivatives suggested them as promising candidates for further studies. On the other hand, the high <jats:italic>in\u2005vitro<\/jats:italic> potency of catechol\u2010type compounds against <jats:italic>T. brucei<\/jats:italic> could not be extrapolated to an <jats:italic>in\u2005vivo<\/jats:italic> mouse model.<\/jats:p>","DOI":"10.1002\/cmdc.201900544","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T08:39:44Z","timestamp":1573115984000},"page":"68-78","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Structure\u2212Activity Relationships of Cinnamate Ester Analogues as Potent Antiprotozoal Agents"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4099-6178","authenticated-orcid":false,"given":"Freddy A.","family":"Bernal","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Pharmazeutische Biologie und Phytochemie (IPBP) Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster  Corrensstra\u00dfe 48 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