{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:54:20Z","timestamp":1789674860042,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T00:00:00Z","timestamp":1575417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01AI136904"],"award-info":[{"award-number":["1R01AI136904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2020,1,17]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Infections caused by multidrug\u2010resistant (MDR) bacteria, particularly Gram\u2010negative bacteria, are an escalating global health threat. Often clinicians are forced to administer the last\u2010resort antibiotic colistin; however, colistin resistance is becoming increasingly prevalent, giving rise to the potential for a situation in which there are no treatment options for MDR Gram\u2010negative infections. The development of adjuvants that circumvent bacterial resistance mechanisms is a promising orthogonal approach to the development of new antibiotics. We recently disclosed that the known IKK\u2010\u03b2 inhibitor IMD\u20100354 potently suppresses colistin resistance in several Gram\u2010negative strains. In this study, we explore the structure\u2013activity relationship (SAR) between the IMD\u20100354 scaffold and colistin resistance suppression, and identify several compounds with more potent activity than the parent against highly colistin\u2010resistant strains of <jats:italic>Acinetobacter baumannii<\/jats:italic> and <jats:italic>Klebsiella pneumoniae<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/cmdc.201900560","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T11:59:17Z","timestamp":1574423957000},"page":"210-218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Structure\u2013Function Studies on IMD\u20100354 Identifies Highly Active Colistin Adjuvants"],"prefix":"10.1002","volume":"15","author":[{"given":"Ansley M.","family":"Nemeth","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Notre Dame  Notre Dame IN 46556 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash K.","family":"Basak","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Notre Dame  Notre Dame IN 46556 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander W.","family":"Weig","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Notre Dame  Notre Dame IN 46556 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiana A.","family":"Marrujo","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Notre Dame  Notre Dame IN 46556 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"Barker","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Notre Dame  Notre Dame IN 46556 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigh A.","family":"Jania","sequence":"additional","affiliation":[{"name":"Department of Genetics University of North Carolina at Chapel Hill  Chapel Hill NC 2759 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler A.","family":"Hendricks","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Notre Dame  Notre Dame IN 46556 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley E.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Notre Dame  Notre Dame IN 46556 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M.","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Notre Dame  Notre Dame IN 46556 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8271-4696","authenticated-orcid":false,"given":"Roberta J.","family":"Melander","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Notre Dame  Notre Dame IN 46556 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly H.","family":"Koller","sequence":"additional","affiliation":[{"name":"Department of Genetics University of North Carolina at Chapel Hill  Chapel Hill NC 2759 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Melander","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Notre Dame  Notre Dame IN 46556 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,4]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"J. O\u2032Neill 2014.The Review on Antimicrobial resistance UK Government and Wellcome Trust."},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/595011"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j4339"},{"key":"e_1_2_7_4_1","unstructured":"\u00a0"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/340353"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa053783"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","unstructured":"M.\u2005F. Richter P.\u2005J. Hergenrother Reaction: Broad-Spectrum Antibiotics a Call for Chemists Vol. 3 Chem2017 pp. 8\u201314.","DOI":"10.1016\/j.chempr.2017.06.014"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70850-3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1586\/eri.12.78"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00343-13"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8070934"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00865-13"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00643"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","unstructured":"A.\u2005M. Caliendo D.\u2005N. Gilbert C.\u2005C. Ginocchio K.\u2005E. Hanson L. May T.\u2005C. Quinn F.\u2005C. Tenover D. Alland A.\u2005J. Blaschke R.\u2005A. Bonomo K.\u2005C. Carroll M.\u2005J. Ferraro L.\u2005R. Hirschhorn W.\u2005P. Joseph T. Karchmer A.\u2005T. MacIntyre L.\u2005B. Reller A.\u2005F. Jackson A. Infectious Diseases Society of Clin Infect Dis2013 57 Suppl 3 S139-170.","DOI":"10.1093\/cid\/cit578"},{"key":"e_1_2_7_15_1","unstructured":"\u00a0"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.7b00071"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2016.06.009"},{"key":"e_1_2_7_18_1","unstructured":"\u00a0"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.8b00161"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2019.03.019"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.9b00135"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2015.09.019"},{"key":"e_1_2_7_23_1","author":"Barker W. T.","year":"2019","journal-title":"ACS Infect. Dis."},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.01.055"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2ob06871k"}],"container-title":["ChemMedChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.201900560","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cmdc.201900560","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.201900560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T14:18:48Z","timestamp":1760278728000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cmdc.201900560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,4]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,1,17]]}},"alternative-id":["10.1002\/cmdc.201900560"],"URL":"https:\/\/doi.org\/10.1002\/cmdc.201900560","archive":["Portico"],"relation":{},"ISSN":["1860-7179","1860-7187"],"issn-type":[{"value":"1860-7179","type":"print"},{"value":"1860-7187","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,4]]},"assertion":[{"value":"2019-10-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}