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The synthetic strategy involves a solvent\u2010free aminolysis reaction catalyzed by zinc\u2010containing species (ZnCl<jats:sub>2<\/jats:sub>, montmorillonite K10 (MK10) impregnated with ZnCl<jats:sub>2<\/jats:sub> or eco\u2010catalysts). The latter have been prepared from the aerial parts of <jats:italic>Lolium perenne<\/jats:italic> L. plants grown on contaminated soils from northern France without and with thermal activation at 120\u2009\u00b0C and supported on MK10 (Ecocat1 and Ecocat2, respectively). The best aminolysis catalysts in the current study (ZnCl<jats:sub>2<\/jats:sub> and Ecocat2) were selected for additional aminolyses. Compared to ZnCl<jats:sub>2<\/jats:sub>, Ecocat2 had the advantage of being reusable over five test runs and constituted a sustainable catalyst allowing a green route to idrocilamide. Synthesized derivatives <jats:bold>1<\/jats:bold>\u2013<jats:bold>4<\/jats:bold>, <jats:bold>6<\/jats:bold> and <jats:bold>9<\/jats:bold> were first evaluated for their effect on reactive oxygen species (ROS) generation from macrophages and displayed antioxidant properties by preventing ROS production. Next, the analysis of the effect of molecules <jats:bold>1<\/jats:bold>\u2013<jats:bold>4<\/jats:bold>, <jats:bold>6<\/jats:bold> and <jats:bold>9<\/jats:bold> on macrophage migration between epithelial cells to human opportunistic fungus <jats:italic>Candida albicans<\/jats:italic> indicated that molecules <jats:bold>2<\/jats:bold>\u2013<jats:bold>4<\/jats:bold>, <jats:bold>6<\/jats:bold> and <jats:bold>9<\/jats:bold> exert anti\u2010inflammatory properties via reducing macrophage migration while the parent idrocilamide (<jats:bold>1<\/jats:bold>) did not show any significant effect. This work opens the way for the discovery of new analogues of idrocilamide with improved properties.<\/jats:p>","DOI":"10.1002\/cmdc.201900641","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T06:23:30Z","timestamp":1580883810000},"page":"459-467","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["New Efficient Eco\u2010Friendly Supported Catalysts for the Synthesis of Amides with Antioxidant and Anti\u2010Inflammatory Properties"],"prefix":"10.1002","volume":"15","author":[{"given":"Pierrick","family":"Dufr\u00e9noy","sequence":"first","affiliation":[{"name":"Laboratoire de chimie durable et sant\u00e9 Yncr\u00e9a Hauts-de-France, UCLille  13 rue de Toul 56046 Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogatien","family":"Charlet","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de Lille  Place Verdun 59045 Lille Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Hechelski","sequence":"additional","affiliation":[{"name":"Institut Sup\u00e9rieur d'Agriculture UCLille  48 boulevard Vauban 59046 Lille Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6942-0519","authenticated-orcid":false,"given":"Adam","family":"Da\u00efch","sequence":"additional","affiliation":[{"name":"UFR des Sciences et Techniques Universit\u00e9 Le Havre Normandie  25 rue Philipe Lebon 76063 Le Havre Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4695-0082","authenticated-orcid":false,"given":"Christophe","family":"Waterlot","sequence":"additional","affiliation":[{"name":"Institut Sup\u00e9rieur d'Agriculture UCLille  48 boulevard Vauban 59046 Lille Cedex France"},{"name":"Institut Sup\u00e9rieur d'Agriculture UCLille  48 boulevard Vauban 59046 Lille Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2759-975X","authenticated-orcid":false,"given":"Samir","family":"Jawhara","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de Lille  Place Verdun 59045 Lille Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6468-4331","authenticated-orcid":false,"given":"Alina","family":"Ghinet","sequence":"additional","affiliation":[{"name":"Laboratoire de chimie durable et sant\u00e9 Yncr\u00e9a Hauts-de-France, UCLille  13 rue de Toul 56046 Lille France"},{"name":"Faculty of Chemistry University of Iasi  Bd. 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