{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:50:03Z","timestamp":1787068203449,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T00:00:00Z","timestamp":1588809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Vietnam National Foundation for Science and Technology Development","award":["104.01-2018.51"],"award-info":[{"award-number":["104.01-2018.51"]}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Korean government","award":["MSIT, NRF-2017\u2005M3\u2005A9G6068246"],"award-info":[{"award-number":["MSIT, NRF-2017\u2005M3\u2005A9G6068246"]}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2020,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have synthesized 50 benzimidazole (BMZ) derivatives with 1,2\u2010phenylenediamines and aromatic aldehydes under mild oxidation conditions by using inexpensive, nontoxic inorganic salt sodium metabisulfite in a one\u2010pot condensation reaction and screened their ability to interfere with Zika virus (ZIKV) infection utilizing a cell\u2010based phenotypic assay. Seven BMZs inhibited an African ZIKV strain with a selectivity index (SI=CC<jats:sub>50<\/jats:sub>\/EC<jats:sub>50<\/jats:sub>) of 9\u201337. Structure\u2010activity relationship analysis demonstrated that substitution at the C\u20102, N\u20101, and C\u20105 positions of the BMZ ring were important for anti\u2010ZIKV activity. The hybrid structure of BMZ and naphthalene rings was a structural feature responsible for the high anti\u2010ZIKV activity. Importantly, BMZs inhibited ZIKV in human neural stem cells, a physiologically relevant system considering the severe congenital anomalies, like microcephaly, caused by ZIKV infection. Compound <jats:bold>39<\/jats:bold> displayed the highest antiviral efficacy against the African ZIKV strain in Huh\u20107 (SI&gt;37) and neural stem cells (SI=12). Compound <jats:bold>35<\/jats:bold> possessed the highest activity in Vero cells (SI=115). Together, our data indicate that BMZs derivatives have to be considered for the development of ZIKV therapeutic interventions.<\/jats:p>","DOI":"10.1002\/cmdc.202000124","type":"journal-article","created":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T22:23:26Z","timestamp":1586730206000},"page":"1453-1463","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Benzimidazole Derivatives as Novel Zika Virus Inhibitors"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4635-933X","authenticated-orcid":false,"given":"Bui Thi Buu","family":"Hue","sequence":"first","affiliation":[{"name":"Department of Chemistry College of Natural Sciences Can Tho University  Campus II, 3\/2 street Ninh Kieu District Can Tho City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuong Hong","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Discovery Biology Division Applied Molecular Virology Laboratory Institut Pasteur Korea 696  Seongnam 13488 Republic of Korea"},{"name":"Division of Bio-Medical Science and Technology University of Science and Technology  Daejeon 34141 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran Quang","family":"De","sequence":"additional","affiliation":[{"name":"Department of Chemistry College of Natural Sciences Can Tho University  Campus II, 3\/2 street Ninh Kieu District Can Tho City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5077-2899","authenticated-orcid":false,"given":"Mai","family":"Van Hieu","sequence":"additional","affiliation":[{"name":"Department of Chemistry College of Natural Sciences Can Tho University  Campus II, 3\/2 street Ninh Kieu District Can Tho City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunji","family":"Jo","sequence":"additional","affiliation":[{"name":"Discovery Biology Division Applied Molecular Virology Laboratory Institut Pasteur Korea 696  Seongnam 13488 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen","family":"Van Tuan","sequence":"additional","affiliation":[{"name":"Department of Chemistry College of Natural Sciences Can Tho University  Campus II, 3\/2 street Ninh Kieu District Can Tho City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Than Thi","family":"Thoa","sequence":"additional","affiliation":[{"name":"Discovery Biology Division Applied Molecular Virology Laboratory Institut Pasteur Korea 696  Seongnam 13488 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Duc","family":"Anh","sequence":"additional","affiliation":[{"name":"Department of Chemistry College of Natural Sciences Can Tho University  Campus II, 3\/2 street Ninh Kieu District Can Tho City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Hoang","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Chemistry College of Natural Sciences Can Tho University  Campus II, 3\/2 street Ninh Kieu District Can Tho City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danh","family":"La Duc Thanh","sequence":"additional","affiliation":[{"name":"Department of Chemistry College of Natural Sciences Can Tho University  Campus II, 3\/2 street Ninh Kieu District Can Tho City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myrielle","family":"Dupont\u2010Rouzeyrol","sequence":"additional","affiliation":[{"name":"URE Dengue and Arboviruses Institut Pasteur de Nouvelle-Cal\u00e9donie  98800 Noumea New Caledonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regis","family":"Grailhe","sequence":"additional","affiliation":[{"name":"Technology Development Platform Institut Pasteur Korea 696  Seongnam 13488 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1874-8503","authenticated-orcid":false,"given":"Marc P.","family":"Windisch","sequence":"additional","affiliation":[{"name":"Discovery Biology Division Applied Molecular Virology Laboratory Institut Pasteur Korea 696  Seongnam 13488 Republic of Korea"},{"name":"Division of Bio-Medical Science and Technology University of Science and Technology  Daejeon 34141 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,7]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1604338"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aag2419"},{"key":"e_1_2_7_4_1","first-page":"13","volume":"6","author":"Desai S. K.","year":"2017","journal-title":"Am. J. Stem Cells"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.12.068"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2013.06.025"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2016.06.010"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00157a010"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2007.10.106"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-827X(02)01300-9"},{"key":"e_1_2_7_11_1","unstructured":"\u00a0"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2011.10.012"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.c13-01009"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.05.009"},{"key":"e_1_2_7_15_1","unstructured":"\u00a0"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.06.060"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2014.07.008"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2016.05.018"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2013.07.083"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.15227\/orgsyn.089.0131"},{"key":"e_1_2_7_21_1","unstructured":"\u00a0"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.12.029"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2013.06.008"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.synthmet.2014.11.005"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dyepig.2016.05.046"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3987\/COM-19-14071"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3gc37004f"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2016.01.042"},{"key":"e_1_2_7_29_1","unstructured":"\u00a0"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.200890203"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-015-0248-x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.02.016"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/v8120322"},{"key":"e_1_2_7_34_1","unstructured":"\u00a0"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-52307-1"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00640-19"},{"key":"e_1_2_7_37_1","unstructured":"\u00a0"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2019.1644967"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.156752"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7OB00945C"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo301805d"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/634914"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41426-018-0166-2"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00725-18"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1089\/adt.2010.0321"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2965"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep44676"},{"key":"e_1_2_7_48_1","unstructured":"\u00a0"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004695"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2016.07.002"}],"container-title":["ChemMedChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcmdc.202000124","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.202000124","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cmdc.202000124","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.202000124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:35:00Z","timestamp":1760276100000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cmdc.202000124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,7]]},"references-count":50,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2020,8,5]]}},"alternative-id":["10.1002\/cmdc.202000124"],"URL":"https:\/\/doi.org\/10.1002\/cmdc.202000124","archive":["Portico"],"relation":{},"ISSN":["1860-7179","1860-7187"],"issn-type":[{"value":"1860-7179","type":"print"},{"value":"1860-7187","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,7]]},"assertion":[{"value":"2020-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}