{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:10:30Z","timestamp":1790755830922,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2021,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The significant antifungal activity of a series of novel 1,2,4\u2010triazole derivatives against different strains of <jats:italic>Candida albicans<\/jats:italic>, <jats:italic>Candida krusei<\/jats:italic> and <jats:italic>Aspergillus fumigatus<\/jats:italic>, compared to the commercial fungicides ketoconazole and itraconazole, is reported. Systemic mycosis and invasive fungal infections, whether from immunodeficiency or hospital\u2010acquired infection, have been on an upward trend for several years. The 1,2,4\u2010triazole ring substituted with other aromatic and heteroaromatic systems plays an important role in the field of antifungal drug discovery and development. Thus, an extensive series of 29\u2005triazoles, substituted in different positions with a variety of aromatic rings, has been designed, synthesized, and evaluated for their fungicidal activity. Almost all the agents tested <jats:italic>in\u2005vitro<\/jats:italic> showed high activity against all examined fungal strains. It is noteworthy that, in the case of <jats:italic>A.\u2005fumigatus<\/jats:italic>, all the examined compounds achieved equal or higher antifungal activity than ketoconazole, but less activity than itraconazole. Among all the derivatives studied, the dichlorourea analogue and bromo\u2010substituted triazole stand out as the most promising compounds. Quantitative structure\u2010activity relationship (QSAR) models were built for a systematic structure\u2010activity relationship (SAR) profile to explain and potentially explore the potency characteristics of 1,2,4\u2010triazole analogues.<\/jats:p>","DOI":"10.1002\/cmdc.202000312","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T22:15:13Z","timestamp":1595369713000},"page":"134-144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The Triazole Ring as a Privileged Scaffold for Putative Antifungals: Synthesis and Evaluation of a Series of New Analogues"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9442-5186","authenticated-orcid":false,"given":"Grigoris","family":"Zoidis","sequence":"first","affiliation":[{"name":"Department of Pharmacy National and Kapodistrian University of Athens Panepistimiopolis-Zografou  15771 Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3975-0832","authenticated-orcid":false,"given":"Eftichia","family":"Kritsi","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology National Hellenic Research Foundation  Vas. Constantinou Ave. 48 11635 Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Lecinska","sequence":"additional","affiliation":[{"name":"Dipartimento di Farmacia-Scienze del Farmaco Universit\u00e0 degli Studi di Bari \u201cAldo Moro\u201d  via E. Orabona 4 70125 Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2480-5490","authenticated-orcid":false,"given":"Marija","family":"Ivanov","sequence":"additional","affiliation":[{"name":"Institute for Biological Research \u201cSini\u0161a Stankovi\u0107\u201d National Institute of the Republic of Serbia University of Belgrade  Bulevar Despota Stefana 142 11000 Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9348-6078","authenticated-orcid":false,"given":"Panagiotis","family":"Zoumpoulakis","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology National Hellenic Research Foundation  Vas. 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